75257-79-3

Basic information

• Product Name: 1,2-Ethanediamine, N-(triphenylmethyl)-
• CAS NO: 75257-79-3
• Molecular Formula: C21H22N2
• Molecular Weight: 302.419
• Mol File: 75257-79-3.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1,2-Ethanediamine, N-(triphenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanediamine, N-(triphenylmethyl)-(75257-79-3)
• EPA Substance Registry System: 1,2-Ethanediamine, N-(triphenylmethyl)-(75257-79-3)

Safety Data

• Hazardous Substances Data: 75257-79-3(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 107-15-3 ethylenediamine 
• 1357108-40-7 (9H-fluoren-9-yl)methyl N-(2-(tritylamino)ethyl)carbamate 

Downstream Products

• 130698-99-6 2,2-Difluoro-N,N'-bis-[2-(trityl-amino)-ethyl]-malonamide 
• 75257-80-6 1-(2,6-dichlorophenyl)-3-<2-<(triphenylmethyl)amino>-ethyl>urea 
• 848770-85-4 5-amino-1-methyl-N-[2-(tritylamino)ethyl]-1H-pyrazole-4-carboxamide 
• 728878-17-9 N-(2-tritylaminoethyl)-4-ethynylbenzamide 
• 1092791-61-1 N-(N'-tritylaminoethyl)-α-D-mannopyranosylamine 
• 1415815-96-1 4-(4-((2-(tritylamino)ethylamino)methyl)phenoxy)phthalonitrile 
• 1415815-95-0 4-((2-(tritylamino)ethylamino)methyl)phenol 

Relevant articles and documents

Synthesis of an aggregation-induced emission (AIE) active salicylaldehyde based Schiff base: Study of mechanoluminescence and sensitive Zn(II) sensing

Syntheses of multi-functional Aggregation-Induced Emission (AIE) active molecules in a simple manner have been drawing great attention in current luminescence materials research. In this report a simple diamine molecule (N1-tritylethane-1,2-dia

Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors

Acute myeloid leukemia (AML) is characterized by fast progression and low survival rates, in which Fms-like tyrosine kinase 3 (FLT3) receptor mutations have been identified as a driver mutation in cancer progression in a subgroup of AML patients. Clinical trials have shown emergence of drug resistant mutants, emphasizing the ongoing need for new chemical matter to enable the treatment of this disease. Here, we present the discovery and topological structure-activity relationship (SAR) study of analogs of isoquinolinesulfonamide H-89, a well-known PKA inhibitor, as FLT3 inhibitors. Surprisingly, we found that the SAR was not consistent with the observed binding mode of H-89 in PKA. Matched molecular pair analysis resulted in the identification of highly active sub-nanomolar azaindoles as novel FLT3-inhibitors. Structure based modelling using the FLT3 crystal structure suggested an alternative, flipped binding orientation of the new inhibitors.

Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s

Quantum dots (QDs) are extremely bright, photostable, nanometer particles broadly used to investigate single molecule dynamics in vitro. However, the use of QDs in vivo to investigate single molecule dynamics is impaired by the absence of an efficient way