752969-85-0

Basic information

• Product Name: 2-amino-5-(trifluoromethoxy)benzothiazole
• CAS NO: 752969-85-0
• Molecular Weight: 234.202
• Mol File: 752969-85-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-5-(trifluoromethoxy)benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-(trifluoromethoxy)benzothiazole(752969-85-0)
• EPA Substance Registry System: 2-amino-5-(trifluoromethoxy)benzothiazole(752969-85-0)

Safety Data

• Hazardous Substances Data: 752969-85-0(Hazardous Substances Data)

Usage

General Description

2-Amino-5-(trifluoromethoxy)benzothiazole is a chemical compound with the molecular formula C8H6F3N3OS. It is a benzothiazole derivative with a trifluoromethoxy group attached to the 5-position and an amino group at the 2-position. 2-amino-5-(trifluoromethoxy)benzothiazole has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. Its unique structure and properties make it a promising candidate for drug discovery and development. Additionally, it may also have uses in other industries such as agrochemicals and materials science. Further research and investigation into the properties and potential applications of 2-amino-5-(trifluoromethoxy)benzothiazole are warranted to fully understand its capabilities and potential uses.

Upstream product

• 1535-73-5 m-trifluoromethoxyaniline 
• 235101-42-5 N-<3-(trifluoromethoxy)phenyl>thiourea 

Relevant articles and documents

Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2- benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-benzothiazolamines bearing alkyl, polyfluoroalkyl, or polyfluoroalkoxy substituents in the 6-position showed potent anticonvulsant activity against administration of glutamic acid in rats. The most active compounds displaying in vivo 'antiglutamate' activity were the 6-OCF3 (riluzole), 6-OCF2CF3, 6-CF3, and 6-CF2CF3 substituted derivatives with ED50 values between 2.5 and 3.2 mg/kg i.p. Among the second series of variously substituted benzothiazolines, compounds as active as riluzole or up to 3 times more potent were identified in two series: benzothiazolines bearing a β-dialkylaminoethyl moiety and compounds with an alkylthioalkyl chain and their corresponding sulfoxides and sulfones. The most potent derivatives were 2-imino-3-(2-methylthio)- and 2-imino-3-(2- methylsulfinyl)-ethyl-6-trifluoromethoxybenzothiazolines (61 and 64, ED50 = 1.0 and 1.1 mg/kg i.p., respectively). In addition, intraperitoneal administration of some of the best benzothiazolines protected mice from mortality produced by hypobaric hypoxia.