753023-57-3Relevant articles and documents
Organocatalytic conjugate addition of cyclopropylacetaldehyde derivatives to nitro olefins: En route to β- and γ-amino acids
Kaasik, Mikk,Noole, Artur,Reitel, K?rt,J?rving, Ivar,Kanger, T?nis
, p. 1745 - 1753 (2015/05/27)
Cyclopropane-containing amino acids are important pharmaceuticals and biologically active compounds. A new organocatalytic asymmetric Michael reaction has been developed. This allows the one-step introduction of the cyclopropane ring, as well as two different nitrogen-containing functional groups (tert-butoxycarbonylamino and nitro) into the target compounds. All the products were isolated in good yields with moderate to excellent enantio- and diastereoselectivities.
ISOXAZOLE β-LACTAMASE INHIBITORS
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Page/Page column 68; 69, (2013/10/21)
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.
Substituted 8'-pyridinyl-dihydrospiro-(cycloalkyl)-pyrimido(1,2-a) pyrimidin-6-one and 8'-pyrimidinyl-dihydrospiro-(cycloalkyl)-pyrimido(1,2-a)pyrimidin-6-one derivatives and their use against neurodegenerative diseases
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Page 9, (2008/06/13)
The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein:X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom;Y represen