75335-04-5

Basic information

• Product Name: 3(2H)-Benzofuranone, 2,2-dimethoxy-
• CAS NO: 75335-04-5
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Mol File: 75335-04-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3(2H)-Benzofuranone, 2,2-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Benzofuranone, 2,2-dimethoxy-(75335-04-5)
• EPA Substance Registry System: 3(2H)-Benzofuranone, 2,2-dimethoxy-(75335-04-5)

Safety Data

• Hazardous Substances Data: 75335-04-5(Hazardous Substances Data)

Upstream product

• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 179538-97-7 2-trifluoromethylsulfonyloxybenzoic acid ethyl ester 
• 67-56-1 methanol 

Relevant articles and documents

A Serendipitous Synthesis of Bis-Heterocyclic Spiro 3(2 H)-Furanones

(Z) Enol triflates 6, 11b-d, (E) enol triflate 11e, and phenol triflate 11a, derived from β-keto esters or 2-carboalkoxy phenols, respectively, react with N-Boc 2-lithiopyrrolidine (5a), N-Boc N-methylaminomethyllithium (5b), or 2-lithio-1,3-dithiane (14) to afford 3(2H)-furanones in modest to good yields (38-81%). Product and carbanion reagent studies suggest that the 3(2H)-furanone is formed in a cascade of reactions involving nucleophilic acyl substitution, enolate formation, trifluoromethyl transfer, iminium or sulfenium ion formation, and subsequent ring closure to form the 3(2H)-furanone. The use of 2-lithio-1,3-dithiane affords a cyclic α-keto-S,S,O-orthoester in which the functionality can be selectively manipulated for synthetic applications. (Chemical Equation Presented).