7535-15-1Relevant articles and documents
Thermodynamic and structural investigations on the complexation process of dioxo macrocyclic ligands: towards neutral copper complexes at Physiological pH
Dechamps-Olivier, Isabelle,Cadiou, Cyril,Harakat, Dominique,Roisnel, Thierry,Chuburu, Francoise,Hodacova, Jana,Koscova, Simona
, p. 2929 - 2941 (2009)
Two dioxotetraza macrocycles 9,12,16,19-tetraazatricyclo[19.4.0.0 2'7]pentacosa-l(21),2,4,6,22,24-hexaene-8,20-dione (L1) and 9,13,16,20-tetraazatricyclo[20.4.0.02,7]hexacosa1(22),2,4,6,23, 25-hexaene-8,21-dione (L2) and two bis(dioxotetraaza) macrocycles 7,10,14,17,25,28,32,35-octaazatetracyclo[17.17,2.05,37.0 23'38]octatriaconta-l,3,5(37), 19,21,23(38)hexaene-6,18,24,36-tetrone (L3) and 7,11,14,18,26,30,33,37octaazatetracyclo[18.18.2.0 5,39.024,40]tetracontal,3,5(39),20,22,24(40)-hexaene-6,19, 25,38-tetrone (L4) were prepared, Their protonation constants and the overall complexation constants of their copper(II) complexes were determined by potentiometry at 25 °C (I = I, KNO3), In aqueous solution, the complexation sequence was elucidated for each ligand by means of UV/Vis and EPR spectroscopy. According to the ligand structure, two coniplexation mechanisms can be characterized, For ligand L1, a neutral complex [CuL1I-L2] is readily obtained in one step at: pH 5, and it is the sole species above pH 7, Its structure was confirmed by X-ray analysis, For ligands L2 and L4, the neutral complexes [CuL2FL-2] and [Cu2L4FLi] were formed by successive deprotonation of [Cu.L2]2+ and [Cu2L4]4+, respectively,
COMPOUNDS TARGETING ALPHA4-BETA7 1NTEGRIN
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Page/Page column 28-30, (2022/01/12)
Compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, are described. The compounds are α4β7 antagonists and are useful in the prevention or treatment of inflammatory conditions and/or autoimmune diseases, especially inflamma
Preparation method of 2,2'-biphenyldicarboxylic acid diallylester
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Page/Page column 4-5, (2019/06/08)
The invention provides a preparation method of 2,2'-biphenyldicarboxylic acid diallylester. The method comprises the following steps: step 1, mixing thionyl chloride with 2,2'-biphenyldicarboxylic acid at the mole ratio of (4 to 5) to 1, adding a catalyst, heating at the temperature of 100-120 DEG C and carrying out reflux reaction for 3-12 hours; step 2, mixing 2,2'-biphenyldicarbonyl chloride prepared in step 1 and allyl alcohol at the mole ratio of 1 to (2 to 3), heating to 100-110 DEG C, carrying out reflux reaction for 4-8 hours, washing until the pH of an aqueous phase is 6, and adding anhydrous magnesium sulfate for drying an organic layer; step 3, adding a polymerization inhibitor into an organic phase prepared by step 2, performing reduced pressure distillation for 1-5 hours to obtain a finished product of 2,2'-biphenyldicarboxylic acid diallylester. The catalyst is one or a combination of any two of N,N'-dimethylformamide and pyridine. The polymerization inhibitor is one of copper powder, cuprous chloride and hydroquinone.