75436-40-7

Basic information

• Product Name: 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester
• Synonyms: 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester;methyl 3-formyl-1H-pyrazole-5-carboxylate
• CAS NO: 75436-40-7
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.12
• Product Categories: Pharmaceutical intermediate
• Mol File: 75436-40-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 373.803 °C at 760 mmHg
• Flash Point: 179.87 °C
• Appearance: /
• Density: 1.394 g/cm³
• PKA: 8.24±0.10(Predicted)
• CAS DataBase Reference: 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester(75436-40-7)
• EPA Substance Registry System: 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester(75436-40-7)

Safety Data

• Hazardous Substances Data: 75436-40-7(Hazardous Substances Data)

Usage

General Description

5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester is a chemical compound with the molecular formula C7H7N3O3. It is a methyl ester derivative of 5-formyl-2H-pyrazole-3-carboxylic acid, containing a pyrazole ring and a formyl group. 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester has potential applications in organic synthesis and pharmaceutical research due to its unique structure and properties. It can be used as a building block in the synthesis of various organic compounds and may have biological activities that could be explored for potential therapeutic applications. Its chemical properties and potential uses make it an interesting and valuable compound for further study and research in the field of chemistry and pharmaceutical science.

Upstream product

• 75436-38-3 methyl 3-(dimethoxymethyl)-1H-pyrazole-5-carboxylate 
• 75436-38-3 methyl 5-[bis(methyloxy)methyl]-1H-pyrazole-3-carboxylate 

Downstream Products

• 1254966-55-6 5-{(Z)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-54-5 5-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2H-pyrazole-3-carboxylic acid methyl ester 

Relevant articles and documents

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)

3-Metoxycarbonyl isoquinolone derivative 1 has been identified as a potent JNK inhibitor and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein, a series of isoquinolones with an imidazolylmethyl or a pyrazolylmethyl group at the 2-position were designed based on X-ray crystallographic analysis of the complex between the isoquinolone compound and JNK3, as wells as the relationship between compound lipophilicity (log D) and activity in a cell-based assay. The compounds prepared showed potent JNK1 inhibitory activities in a cell-based assay. Among them the isoquinolone derivative possessing 5-[(cyclopropylamino)carbonyl]-1-methyl-1H-pyrazole (16e) exhibited significant anti-hypertrophic activity at doses of more than 1 mg/kg (po) in a pressure-overload model.

LE DIMETHYL ACETAL DU DIAZOACETALDEHYDE : UNENOUVELLE VOIE D'ACCES AUX CYCLOPROPANES ALDEHYDES ET AUX FORMYL PYRAZOLES.

Diazoacetaldehyde dimethylacetal 1 is a readily accessible and highly reactive 1,3 dipole.Starting from 1, both electrophilic cyclopropanes with an extra aldehyde function and formyl pyrazoles are prepared in high yields.