75508-72-4

Basic information

• Product Name: 1-(2-Methoxy-phenyl)-3-methyl-butan-2-one
• Synonyms: 1-(2-Methoxy-phenyl)-3-methyl-butan-2-one
• CAS NO: 75508-72-4
• Molecular Weight: 192.258
• Mol File: 75508-72-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-Methoxy-phenyl)-3-methyl-butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Methoxy-phenyl)-3-methyl-butan-2-one(75508-72-4)
• EPA Substance Registry System: 1-(2-Methoxy-phenyl)-3-methyl-butan-2-one(75508-72-4)

Safety Data

• Hazardous Substances Data: 75508-72-4(Hazardous Substances Data)

Usage

Molecular Weight

192.25 g/mol

Physical State

Colorless liquid

Aroma

Sweet, floral

Uses

Fragrance ingredient in perfumes and personal care products
Potential use in pharmaceutical and food industries

Properties

Anti-inflammatory
Antioxidant

Synthesis

Identified as a potential precursor in the synthesis of biologically active compounds

Toxicity

Generally considered to have low toxicity

Safety

Safety and potential health effects should be carefully evaluated before use in any application

Upstream product

• 69875-71-4 1,1-dimethyl-2-(trimethylsiloxy)allyl chloride 
• 100-66-3 methoxybenzene 
• 5950-19-6 3-chloro-3-methyl-2-butanone 

Downstream Products

• 28748-41-6 2-(1-methylethyl)benzofuran 

Relevant articles and documents

Generation of 2-(Trimethylsiloxy)allyl Cations and Their Reactions with 1,3-Dienes. Change in Mechanism of 3 + 4 -> 7 Cycloaddition with Solvent

A series of 12 different 2-(trimethylsiloxy)allyl cations 34a-l is generated from various 2-(trimethylsiloxy)allyl chlorides (3-5) with silver perchlorate.In nitromethane solution, all the cations smoothly react with furan and cyclopentadiene in a 3 + 4 -> 7 manner to give a comprehensive series of 8-oxabicyclooct-6-en-3-ones and bicyclooct-6-en-3-ones in good yields.The cycloaddition with furan proceeds in a stereospecific manner with the retention of allyl cation configurations, in accord with a concerted mechanism.The 3 + 4 -> 7 reactions in THF/ether contrast with those in nitromethane in the following ways. (1) The yield of the adducts strongly depends on the strusture of the allyl cations. (2) The reaction with furan is nonstereospecific. (3) An electrophilic substitution reaction strongly compets with the cycloaddition. (4) The cycloaddition between the cation 34a and 2-methylfuran is highly regioselective (11/12 = 19) as compared to that in nitromethane (the ratio being only 1.9).These findings in THF/ether are reasonably explained by a stepwise mechanism via an intermediate 40.Reactions with acyclic dienes (isoprene and 2,3-dimethylbutadiene), naphthalene, anisole, and methanol are also described.