756503-69-2

Basic information

• Product Name: 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
• Synonyms: 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
• CAS NO: 756503-69-2
• Molecular Formula: C₁₃H₁₀BrCl₂FN₂O
• Molecular Weight: 380.0397032
• Mol File: 756503-69-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 423.4°C at 760 mmHg
• Flash Point: 209.9°C
• Appearance: /
• Density: 1.643g/cm³
• Vapor Pressure: 2.24E-07mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine(756503-69-2)
• EPA Substance Registry System: 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine(756503-69-2)

Safety Data

• Hazardous Substances Data: 756503-69-2(Hazardous Substances Data)

Usage

General Description

5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is a chemical compound with a molecular formula of C14H10BrCl2F2N3O and a molecular weight of 409.05 g/mol. It is a pyridine derivative that contains a bromo group, a fluoro group, and two chloro groups on its phenyl ring. 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is commonly used in pharmaceutical research and drug development as it has potential biological activities. Its structure suggests that it may have applications in the treatment of various ailments. The compound's unique chemical properties make it an interesting target for further study and potential development.

InChI:InChI=1/C13H10BrCl2FN2O/c1-6(11-8(15)2-3-9(17)12(11)16)20-10-4-7(14)5-19-13(10)18/h2-6H,1H3,(H2,18,19)

Upstream product

• 15128-82-2 3-hydroxy-2-nitropyridine 
• 691872-15-8 5-bromo-3-hydroxy-2-nitropyridine 
• 74115-13-2 5-bromopyridine-3-ol 
• 290835-85-7 2',6'-dichloro-3'-fluoroacetophenone 
• 756521-08-1 (±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine 
• 756520-66-8 1-(2,6-dichloro-3-fluorophenyl)ethanol 
• 756520-67-9 (±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 
• 1331786-28-7 2-(1-bromoethyl)-1,3-dichloro-4-fluorobenzene 
• 39903-01-0 2-amino-3-hydroxy-5-bromopyridine 

Downstream Products

• 1023327-92-5 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(2-methoxypyrimidin-5-yl)-pyridin-2-amine 
• 1023327-97-0 cyclopentyl 5-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-phenoxy)-N-tert-butoxycarbonyl-L-norvalinate 
• 756508-98-2 6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-nicotinonitrile 
• 877399-36-5 tert-butyl 3-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate 
• 1331786-34-5 (±)-bis(Boc)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine 
• 877399-08-1 (±)-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 
• 877400-66-3 (+/-)-PF023401066 
• 877401-42-8 tert-butyl 4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1331786-33-4 (±)-bis(Boc)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine 

Relevant articles and documents

Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants

Despite the initial benefit demonstrated in clinical setting with ALK inhibitors, the challenging resistant mutants (F1174L, L1196M and G1202R) invariably developed. In this work, a series of 2-aminopyridine derivatives were designed and synthesized by C-5 position incorporation of a 2-pyridone moiety and bioisosteric replacement of the C-3 position linkers. Optimization of the 2-aminopyridine derivatives led to the identification of hit 18d displaying a significant growth inhibition against a variety of ALK-addicted cancer cells. Especially in the case of ALK-positive Karpas-299 cell, 18d exhibited excellent anti-proliferative potency with an IC50 value of about 40 nM. Moreover, 18d demonstrated encouraging activities against wild-type ALK (19 nM), ROS1 (2.3 nM) as well as challenging crizotinib-resistant ALKL1196M and ALKG1202R mutants with IC50 values of 45 nM and 22 nM, respectively. Additionally flow cytometric analysis indicates that 18d inhibited Karpas-299 cell viability via G1 phase arrest. Taken together, this work provided a promising ALK inhibitor to circumvent the clinical crizotinib-resistant mutants.

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

AMINO HETEROARYL COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention refers to aminoheteroaryl compounds of the following formula (I) as well as the preparation method and use thereof, wherein R1 and R3 are defined in the Description in details. The aminoheteroaryl compounds of t