75714-60-2

Basic information

• Product Name: (R)-3,3'-DIBROMO-2,2'-DIMETHOXY-1,1'-BINAPHTHYL
• Synonyms: 3,3'-DIBROMO-1,1'-BI-2-NAPHTHOL DIMETHYL ETHER;3,3'-DIBROMO-2,2'-DIMETHOXY-1,1'-BINAPHTHYL;(R)-3,3'-DIBROMO-1,1'-BI-2-NAPHTHOL DIMETHYL ETHER;(S)-3,3'-DIBROMO-2,2'-DIMETHOXY-1,1'-BINAPHTHYL;(S)-3,3'-DIBROMO-1,1'-BI-2-NAPHTHOL DIMETHYL ETHER;(S)-3 3'-DIBROMO-2 2'-DIMETHOXY-1 1'-BI&;(S)-3,3'-Dibromo-2,2'-dimethoxy-1,1'-binaphthyl;(S)-3,3'-Dibromo-2,2'-Dimethoxy-1-Binaphthyl
• CAS NO: 75714-60-2
• Molecular Formula: C₂₂H₁₆Br₂O₂
• Molecular Weight: 472.17
• Product Categories: chiral;Asymmetric Synthesis;Synthetic Organic Chemistry
• Mol File: 75714-60-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 180.0 to 185.0 °C
• Boiling Point: 468.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.556±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: almost transparency in Chloroform
• CAS DataBase Reference: (R)-3,3'-DIBROMO-2,2'-DIMETHOXY-1,1'-BINAPHTHYL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3,3'-DIBROMO-2,2'-DIMETHOXY-1,1'-BINAPHTHYL(75714-60-2)
• EPA Substance Registry System: (R)-3,3'-DIBROMO-2,2'-DIMETHOXY-1,1'-BINAPHTHYL(75714-60-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36/37-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 75714-60-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 74-88-4 methyl iodide 
• 75640-87-8 (S)-2,2'-dimethoxy-1,1'-dinaphthyl 
• 75685-01-7 2,2'-dimethoxy-1,1'-binaphthyl 

Downstream Products

• 75640-71-0 (S)-3,3'-Bis(pentamethylphenyl)-2,2'-dihydroxy-1,1'-dinaphthyl 
• 791616-60-9 (S)-3,3'-bis(4-nitrophenyl)-1,1'-binaphthalene-2,2'-diol 
• 215433-51-5 (S)-3,3’-bis(3,5-dimethylphenyl)-[1,1‘-binaphthalene]-2,2’-diol 

Relevant articles and documents

Oxidation of BINOLs by Hypervalent Iodine Reagents: Facile Synthesis of Xanthenes and Lactones

Xanthene derivatives have broad applications in medicines, fluorescent probes, dyes, food additives, etc. Therefore, much attention was focused on developing the synthetic methods to prepare these compounds. Binaphthyl-based xanthene derivatives were prepared through the oxidation of BINOLs promoted by the hypervalent iodine reagent iodosylbenzene (PhIO). Nine-membered lactones were obtained through a similar oxidative reaction when iodoxybenzene (PhIO2) was used. Additionally, one-pot reactions of BINOLs, PhIO and nucleophiles such as alcohols and amines were also investigated to provide alkoxylated products and amides in good to excellent yields.

INHIBITORS OF GLUCOSE TRANSPORTERS (GLUTS)

The present invention relates to 2,6-methanobenzo[g][1]oxacin-4-onecompounds and their analog compounds and pharmaceutically acceptable salts thereof as selective inhibitor of glucose transporters 1 and 3 (GLUTs 1 and 3), to methods of preparing said compounds, and to the use thereof as pharmaceutically active agents, especially for the prophylaxis and/or treatment of metabolic diseases, immunological diseases, autoimmune diseases, inflammation, graft versus host disease, cancer, and metastasis thereof. Furthermore, the present invention is directed to pharmaceutical composition comprising at least one of 2,6-methanobenzo[g][1]oxacin-4-one compounds and their analog compounds.

RETRACTED ARTICLE: Enantioselective organocatalytic hantzsch synthesis of polyhydroquinolines

The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent ee's. Through catalyst scr