757232-69-2

Basic information

• Product Name: (2R,3R)-ethyl 2-bromo-3-hydroxy-3-phenylpropanoate
• Synonyms: (2R,3R)-ethyl 2-bromo-3-hydroxy-3-phenylpropanoate
• CAS NO: 757232-69-2
• Molecular Weight: 273.126
• Mol File: 757232-69-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3R)-ethyl 2-bromo-3-hydroxy-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-ethyl 2-bromo-3-hydroxy-3-phenylpropanoate(757232-69-2)
• EPA Substance Registry System: (2R,3R)-ethyl 2-bromo-3-hydroxy-3-phenylpropanoate(757232-69-2)

Safety Data

• Hazardous Substances Data: 757232-69-2(Hazardous Substances Data)

Upstream product

• 163893-32-1 (4S,5R)-2-Oxo-5-phenyl-2λ⁴-[1,3,2]dioxathiolane-4-carboxylic acid ethyl ester 
• 163960-83-6 (4S,5R)-2,2-Dioxo-5-phenyl-2λ⁶-[1,3,2]dioxathiolane-4-carboxylic acid ethyl ester 
• 108741-12-4 ethyl (2S,3R)-2,3-dihydroxy-3-phenylpropanoate 
• 62317-42-4 ethyl (+/-)-3-acetoxy-2-bromo-3-phenylpropanoate 

Downstream Products

• 121-39-1 (2S,3R)-ethyl 3-phenyloxirane-2-carboxylate 
• 115794-66-6 trans-methyl 3-phenylglycidate 

Relevant articles and documents

Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain

The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of tran

Efficient synthesis of chiral α,β-epoxyesters via a cyclic sulfate intermediate

An efficient synthesis of chiral α,β-epoxyester 1 from chiral 2,3- dihydroxyester 2 has been developed. Ester 2 is converted to the corresponding cyclic surfate 3, which is opened with either LiBr in THF or Bu4NBr in acetone at rt to furnish 2-bromo-3-hydroxyester 4. Treatment of 4 with K2CO3 in methanol at low temperature gives α,β-epoxyester 1 in excellent overall yield and in the same ee as in the starting diol.