75776-48-6Relevant articles and documents
A One-step Synthesis of 2,4-Bis(sec-alkylamino)-6-halo-3-pyridinecarbonitriles
Metzger, Roland,Oberdoerfer, Juergen,Schwager, Carlos,Thielecke, Wilfried,Boldt, Peter
, p. 946 - 953 (2007/10/02)
The title compounds, e.g. 2a-c or 7, are obtained by reaction of malononitrile (1) with sec-alkylhalides/aluminium chloride (except the alkyl fluorides) at room temperature.From these the corresponding 2,4-bis(sec-alkylamino)pyridines may be conveniently prepared.With hydrogen bromide, 1 or its "dimer" 10 (R = H) 2,4-diamino-6-bromo-5-pyridinecarbonitrile (17) is formed.