76005-99-7

Basic information

• Product Name: 2-METHOXY-3-AMINO-4-PICOLINE
• Synonyms: 2-METHOXY-3-AMINO-4-PICOLINE;2-Methoxy-4-methyl-3-pyridinamine;2-Methoxy-4-Methylpyridin-3-aMine;3-PyridinaMine, 2-Methoxy-4-Methyl-;2-Methoxy-4-methyl-pyridin-3-ylamine
• CAS NO: 76005-99-7
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.1671
• Product Categories: Pyridine
• Mol File: 76005-99-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 265℃
• Flash Point: 114℃
• Appearance: /
• Density: 1.103
• Vapor Pressure: 0.00921mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 4.99±0.18(Predicted)
• CAS DataBase Reference: 2-METHOXY-3-AMINO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-3-AMINO-4-PICOLINE(76005-99-7)
• EPA Substance Registry System: 2-METHOXY-3-AMINO-4-PICOLINE(76005-99-7)

Safety Data

• Hazardous Substances Data: 76005-99-7(Hazardous Substances Data)

Usage

General Description

2-METHOXY-3-AMINO-4-PICOLINE is a chemical compound with the molecular formula C7H8N2O and a molecular weight of 136.15 g/mol. It is a derivative of pyridine, with a methyl group and an amino group at the 2 and 3 positions, respectively, and a methoxy group at the 4 position. 2-METHOXY-3-AMINO-4-PICOLINE is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceuticals, including anti-inflammatory and anticancer agents. It is also used in organic synthesis and as a ligand in coordination chemistry. 2-METHOXY-3-AMINO-4-PICOLINE is a yellowish-brown liquid at room temperature and is soluble in organic solvents. It should be handled and stored with care due to its potential hazards.

InChI:InChI=1/C7H10N2O/c1-5-3-4-9-7(10-2)6(5)8/h3-4H,8H2,1-2H3

Upstream product

• 160590-36-3 2-methoxy-4-methyl-3-nitropyridine 
• 67-56-1 methanol 
• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 

Downstream Products

• 1417332-43-4 3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (2-methoxy-4-methyl-pyridin-3-yl)-amide 
• 76006-25-2 7-anilino-1H-pyrazolo<3,4-c>pyridine 
• 76006-10-5 7-methoxy-1H-pyrazolo<3,4-c>pyridine 
• 76006-09-2 1H-pyrazolo<3,4-c>pyridin-7(6H)-one 
• 76006-11-6 7-chloro-1H-pyrazolo<3,4-c>pyridine 

Relevant articles and documents

A pyrazolopyridine compound and method for preparing the same

The invention relates to a pyrazolopyridine compound and a preparation method thereof. The compound is 3-bromo-1H-pyrazolo[3,4-c]pyridine-7(6H)-one, and the preparation method comprises the following steps: (1) by taking the compound 1 2-chloro-3-amino-4methylpyridine as a starting raw material, etherifying 2-chloro-3-amino-4methylpyridine through sodium methoxide under the catalysis of copper iodide; (2) closing pyrazole ring through isoamyl nitrite; (3) feeding pyrazol-3 through NBS (N-Bromosuccinimide); (4) removing methoxyl to obtain phenyl (mixture difficult to separate) through pyridine hydrochloride; (5) performing acetyl protection to the obtained mixture so as to separate and purify; and (6) deacetylating through using potassium carbonate as a base to obtain a final product; and according to the preparation method, the mixture difficult to purify in the reaction process is conveniently separated and purified by adopting a method of performing protection and then removing protection, and the purification difficulty caused by instability of an intermediate product can be solved.

NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine alpha7 receptor.

Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides

The preparation of novel 5-amino or 7-hydroxy substituted pyrazolo[4,3-b]pyridine and pyrazolo[3,4-c]pyridine acyclic C-nucleosides is described. Their synthesis was carried out by condensation of suitably substituted lithiated picolines with 2-benzyloxyethoxymethylchloride followed by pyrazole ring annulation. The compounds were evaluated for their antiviral activity against a wide panel of viruses, but were found inactive at subtoxic concentrations.