76016-68-7

Basic information

• Product Name: 1,2,5-Oxadiazole, 3-nitro-4-phenyl-
• Synonyms: 3-nitro-4-phenyl-furazan;3-NITRO-4-PHENYL-1,2,5-OXADIAZOLE;1,2,5-Oxadiazole, 3-nitro-4-phenyl-
• CAS NO: 76016-68-7
• Molecular Formula: C₈H₅N₃O₃
• Molecular Weight: 191.14
• Mol File: 76016-68-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 41-42 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 333.4±34.0 °C(Predicted)
• Appearance: /
• Density: 1.407±0.06 g/cm3(Predicted)
• PKA: -6.39±0.30(Predicted)
• CAS DataBase Reference: 1,2,5-Oxadiazole, 3-nitro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Oxadiazole, 3-nitro-4-phenyl-(76016-68-7)
• EPA Substance Registry System: 1,2,5-Oxadiazole, 3-nitro-4-phenyl-(76016-68-7)

Safety Data

• Hazardous Substances Data: 76016-68-7(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains an oxadiazole ring and a nitro group

Applications

a. Production of pharmaceuticals
b. Production of agrochemicals

Biological activities

a. Anti-inflammatory properties
b. Antibacterial properties

Potential use in drug design

Bioisosteric replacement for carboxylic acid and amide functional groups

Fields of interest

Medicinal chemistry and drug development

Upstream product

• 29945-54-8 3-amino-4-phenylfuroxane 
• 10349-14-1 4-phenyl-furazan-3-ylamine 

Downstream Products

• 24785-82-8 3-hydroxy-4-phenylfurazan 
• 372945-78-3 3-(2-Hydroxyethylthio)-4-phenylfurazan 
• 1226460-34-9 tetraethyl (5-(4-phenylfurazan-3-yloxy)pentylidene)bisphosphonate 
• 76016-70-1 3-Phenylsulfonyl-4-phenylfurazan 
• 124940-65-4 3-Phenyl-4-trimethylsilanyloxy-furazan 
• 124940-66-5 2-ethyl-4-phenyl-1,2,5-oxadiazol-3(2H)-one 
• 24785-81-7 3-ethoxy-4-phenylfurazan 
• 372945-83-0 3-(Carbamoylmethylsulfonyl)-4-phenylfurazan 
• 372945-88-5 2-(4-phenyl-furazan-3-yloxy)-ethanesulfinic acid 
• 372945-79-4 3-(2-Hydroxyethylsulfonyl)-4-phenylfurazan 
• 10349-15-2 3-(Acetylamino)-4-phenylfurazan 

Relevant articles and documents

Reactions of furoxanyl and furazanyl diazonium salts with NaNO2 in weakly acidic medium, a new approach to the preparation of nitrofuroxans and nitrofurazans

A new approach to the preparation of nitrofuroxans and nitrofurazans is suggested based on the diazotization of aminofuroxans and aminofurazans in aqueous organic medium at pH = 4-5 in the presence of excess NaNO2.

SYNTHESIS OF ISOMERIC 3-NITRO-4-PHENYLFUROXANE AND 4-NITRO-3-PHENYLFUROXANE

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Antimicrobial properties of some furazan and furoxan derivatives

Nitro and phenylsulfonyl derivatives of furazan and furoxan ring systems have been synthesized and tested in vitro for their antimicrobial properties. The nitro derivatives and the 4-phenyl-3-phenyl sulphonylfuroxan showed antibacterial, antifungal and antiprotozoal activity.