76149-15-0

Basic information

• Product Name: 4-(2-di-N-propylaminoethyl)indole
• Synonyms: 4-(2-di-N-propylaminoethyl)indole;Desoxo-2-ene Ropinirole
• CAS NO: 76149-15-0
• Molecular Formula: C₁₆H₂₄N₂
• Molecular Weight: 244.38
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 76149-15-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 387.4°C at 760 mmHg
• Flash Point: 188.1°C
• Appearance: /
• Density: 1.014g/cm³
• Vapor Pressure: 3.3E-06mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 4-(2-di-N-propylaminoethyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-di-N-propylaminoethyl)indole(76149-15-0)
• EPA Substance Registry System: 4-(2-di-N-propylaminoethyl)indole(76149-15-0)

Safety Data

• Hazardous Substances Data: 76149-15-0(Hazardous Substances Data)

Usage

Uses

Desoxo-2-ene Ropinirole has shown little to not effect on postsynaptic dopamine receptors, however its derivatives are dopamine agonists.

InChI:InChI=1/C16H24N2/c1-3-11-18(12-4-2)13-9-14-6-5-7-16-15(14)8-10-17-16/h5-8,10,17H,3-4,9,11-13H2,1-2H3

Upstream product

• 16176-73-1 2-(1H-indol-4-yl)ethan-1-amine 
• 107-08-4 1-iodo-propane 
• 49839-99-8 4-(2-nitrovinyl)indole 
• 1074-86-8 4-formyl indole 
• 32666-56-1 1-amino-5,8-dihydronaphthalene 
• 134-32-7 1-amino-naphthalene 
• 802294-64-0 propionic acid 
• 115348-05-5 1-acetamido-5,8-dihydronaphthalene 
• 31110-58-4 2-<(1-acetyl)-4-indolyl>acetaldehyde 
• 84401-12-7 benzyl 1-benzoylindole-4-carboxylate 
• 84401-14-9 1-benzoyl-4-diazoacetylindole 
• 84401-13-8 1-benzoylindole-4-carboxylic acid 
• 344320-85-0 1-Benzoyl-1H-indole-4-carbonyl chloride 
• 84401-11-6 benzyl indole-4-carboxylate 

Downstream Products

• 91374-21-9 Ropinirole 

Relevant articles and documents

Proposed dopaminergic pharmacophore of lergotrile, pergolide, and related ergot alkaloid derivatives

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The development of a short route to the API ropinirole hydrochloride

A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.

Preparation of alkyl-substituted indoles in the benzene portion. Part 5. Efficient preparative procedure for 4-substituted indole derivatives

An effective and short synthetic method for 4-substituted indole derivatives was developed based on the two sequential reactions, i.e. nucleophilic addition of carbanions to common precursor molecules, 3-(1,3-dioxolan-2-yl)-1-[1(phenylsulfonyl)- and 1-[(4