76162-55-5

Basic information

• Product Name: ethyl 3-(p-methoxyphenyl)-1,2,4-thiadiazole-5-carboxylate
• Synonyms: ethyl 3-(p-methoxyphenyl)-1,2,4-thiadiazole-5-carboxylate
• CAS NO: 76162-55-5
• Molecular Weight: 264.305
• Mol File: 76162-55-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: ethyl 3-(p-methoxyphenyl)-1,2,4-thiadiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(p-methoxyphenyl)-1,2,4-thiadiazole-5-carboxylate(76162-55-5)
• EPA Substance Registry System: ethyl 3-(p-methoxyphenyl)-1,2,4-thiadiazole-5-carboxylate(76162-55-5)

Safety Data

• Hazardous Substances Data: 76162-55-5(Hazardous Substances Data)

Upstream product

• 71309-86-9 4-Methoxybenzonitrilsulfid 
• 623-49-4 ethyl cyanoformate 
• 52533-09-2 5-(4-methoxyphenyl)-[1,3,4]oxathiazol-2-one 
• 104478-87-7 5-(p-chlorophenyl)-3-(p-methoxyphenyl)-4-phenyl-4,5-dihydro-1,2,4-thiadiazole 
• 73501-03-8 5-(p-methoxyphenyl)-2,2-bis(trichloromethyl)-1,3,4-oxathiazole 

Downstream Products

• 1068106-46-6 5-hydroxymethyl-3-(4-methoxyphenyl)-1,2,4-thiadiazole 

Relevant articles and documents

ANTIBACTERIAL AGENTS

Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is =CH- or =N-; Ri and R2 are independently selected from hydrogen, fluoro and chloro, provided that Ri and R2 are not each hydrogen when W is =CH-; n is 0 or 1; X is -O-, -S-, or -C

Heteroarylnitrones as drugs for neurodegenerative diseases: Synthesis, neuroprotective properties, and free radical scavenger properties

New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative damage and the death induced by exposure to hydrogen peroxide. These heteroarylnitrones showed excellent peroxyl free radical absorbance capacities, analyzed by oxygen radical absorbance capacity (ORAC) assay with fluorescein as the fluorescent probe, ranging from 1.5- to 16.5-fold the value of the reference nitrone, α-phenyl-N-tert-butylnitrone (PBN). The electron spin resonance spectroscopy (ESR) demonstrated the ability of these derivatives to directly trap and stabilize oxygen, carbon, and sulfur-centered free radicals. These results demonstrated the potential use of these heteroarylnitrones as neuroprotective agents in preventing the death of cells exposed to enhanced oxidative stress and damage.

Nitrile Sulphides. Part 5. 1,3-Dipolar Cycloaddition of p-Methoxybenzonitrile Sulphide to Imines and Crystal Structure of One of the Resulting 4,5-Dihydro-1,2,4-thiadiazoles

p-Methoxybenzonitrile sulphide, generated by thermal fragmentation of the corresponding 1,3,4-oxathiazol-2-one, undergoes 1,3-dipolar cycloaddition to imines forming 4,5-dihydro-1,2,4-thiadiazoles.X-ray crystal structure analysis shows that the heterocyclic ring is non-planar with a fold of 30 deg about the S(1) - N(4) vector.