76219-45-9

Basic information

• Product Name: (4-nitrophenyl)methyl diphenylphosphinate
• Synonyms: (4-nitrophenyl)methyl diphenylphosphinate
• CAS NO: 76219-45-9
• Molecular Weight: 353.314
• Mol File: 76219-45-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (4-nitrophenyl)methyl diphenylphosphinate(CAS DataBase Reference)
• NIST Chemistry Reference: (4-nitrophenyl)methyl diphenylphosphinate(76219-45-9)
• EPA Substance Registry System: (4-nitrophenyl)methyl diphenylphosphinate(76219-45-9)

Safety Data

• Hazardous Substances Data: 76219-45-9(Hazardous Substances Data)

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 1707-03-5 diphenyl-phosphinic acid 
• 4559-70-0 Diphenylphosphine oxide 
• 17223-05-1 diphenylphosphinic acid potassium salt 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 99-99-0 1-methyl-4-nitrobenzene 

Relevant articles and documents

Highly Efficient and Convenient Access to Phosphinates via CHCl3-Assisted Direct Phosphorylation between R2P(O)H and ROH by Phosphonium Salt Catalysis

A mild, efficient, convenient and scalable method to synthesize phosphinates via direct phosphorylation between R2P(O)H and ROH was developed. All aromatic substrates completed this transformation with excellent yields (up to 98 %), and preliminary mechanistic studies suggest that a carbene-involving process from CHCl3 to CH2Cl2 facilitates the phosphorylation.

DCC-assisted direct esterification of phosphinic and phosphoric acids with O-nucleophiles

A novel and efficient dicyclohexylcarbodiimide-promoted protocol for the selective and controllable esterification of P(O)OH compounds using O-nucleophiles (alcohols and phenols) as efficient esterification reagents is described. This method features a high efficiency and good functional-group tolerance, meaning a simple way to synthesize a broad spectrum of phosphinic and phosphoric acid esters from basic starting materials with moderate to excellent yields.

Method for preparing organophosphate compound from P(O)-OH-containing compound and alcohol through efficient esterification

The invention provides a method for efficiently and highly selectively synthesizing an organophosphate derivative containing different substitute functional groups. The method is characterized by adopting a polypeptide catalyst as a condensation reagent, taking a P(O)-OH-containing compound and alcohol as reaction substrates, and adding an organic solvent in a reaction system. The method disclosed by the invention has the advantages that the catalyst is cheap in cost and easy to obtain; the substrate applicability is high; reaction conditions are mild, safe and reliable; the selectivity of an obtained target product is close to 100 percent, and the yield is up to 90 percent or more. According to the method provided by the invention, the defects of a traditional method for synthesizing an organophosphate compound that the reaction selectivity is poor, the reaction steps are tedious, the yield is low, reagents which are harmful to the environment are required to be used, and the like are solved, and a good industrial application prospect is obtained. Meanwhile, the invention also provides the corresponding organophosphate derivative containing different substitute functional groups.