76263-65-5

Basic information

• Product Name: (E)-1-((4-Methylphenyl)sulfonyl)-3-(phenylmethylene)-2,3-dihydro-4(1H) -quinolinone
• Synonyms: (E)-1-((4-Methylphenyl)sulfonyl)-3-(phenylmethylene)-2,3-dihydro-4(1H) -quinolinone
• CAS NO: 76263-65-5
• Molecular Formula: C₂₃H₁₉NO₃S
• Molecular Weight: 389.47
• Mol File: 76263-65-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 585.3°C at 760 mmHg
• Flash Point: 307.8°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 1.1E-13mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: (E)-1-((4-Methylphenyl)sulfonyl)-3-(phenylmethylene)-2,3-dihydro-4(1H) -quinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-((4-Methylphenyl)sulfonyl)-3-(phenylmethylene)-2,3-dihydro-4(1H) -quinolinone(76263-65-5)
• EPA Substance Registry System: (E)-1-((4-Methylphenyl)sulfonyl)-3-(phenylmethylene)-2,3-dihydro-4(1H) -quinolinone(76263-65-5)

Safety Data

• Hazardous Substances Data: 76263-65-5(Hazardous Substances Data)

Usage

General Description

(E)-1-((4-Methylphenyl)sulfonyl)-3-(phenylmethylene)-2,3-dihydro-4(1H)-quinolinone, also known as MS11, is a chemical compound with potential antitumor and anti-inflammatory properties. It is a synthetic compound that belongs to the class of quinolinone derivatives and acts as a selective inhibitor of the enzyme indoleamine 2, 3-dioxygenase (IDO). IDO plays a key role in the regulation of T-cell function and is overexpressed in various tumors, making it an attractive target for cancer therapy. Additionally, MS11 has been found to have potent anti-inflammatory effects, which makes it a potential candidate for the treatment of inflammatory diseases. Further research and development of this compound could lead to the creation of novel therapeutic agents for cancer and inflammatory conditions.

InChI:InChI=1/C23H19NO3S/c1-17-11-13-20(14-12-17)28(26,27)24-16-19(15-18-7-3-2-4-8-18)23(25)21-9-5-6-10-22(21)24/h2-15H,16H2,1H3/b19-15+

Upstream product

• 100-52-7 benzaldehyde 
• 665033-49-8 N-[2-(3-hydroxy-prop-1-ynyl)-phenyl]-4-methyl-benzenesulfonamide 
• 622-58-2 p-Tolylisocyanate 
• 114837-50-2 2-bromo-α-(ethenyl)benzenemethanol 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 71095-56-2 1-(2-bromophenyl)-2-propen-1-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 108-73-6 3,5-dihydroxyphenol 
• 615-43-0 2-iodophenylamine 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 61613-20-5 N-tosyl-2-iodoaniline 
• 2687-12-9 cinnamyl chloride 
• 1224712-78-0 N-(3-phenyl-prop-2-ynyl)-N-(2-formyl-phenyl)-4-methyl-benzenesulfonamide 
• 62-53-3 aniline 

Downstream Products

• 103688-25-1 3-phenyl-2H-pyrazolo<4,3-c>quinoline 
• 103688-26-2 2,3-diphenyl-2H-pyrazolo<4,3-c>quinoline 
• 103688-27-3 4,5-dihydro-2,3-diphenyl-2H-pyrazolo<4,3-c>quinoline 
• 103688-17-1 4.5-dihydro-3-phenyl-5-tosyl-2H-pyrazolo<4,3-c>quinoline 
• 103688-23-9 2-acetyl-4,5-dihydro-3-phenyl-5-tosyl-2H-pyrazolo<4,3-c>quinoline 
• 103688-18-2 2,3-Diphenyl-5-(toluene-4-sulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline 
• 103688-12-6 C₂₃H₁₉NO₄S 
• 76298-68-5 2-acetyl-3-phenyl-5-tosyl-3,3a,4,5-tetrahydropyrazolo<4,3-c>quinoline 

Relevant articles and documents

A 3 - aryl - 2, 3 - dihydro -4 (1 H) - quinolinone of preparation method

The invention provides a 3 - aryl - 2, 3 - dihydro - 4 (1 H) - quinolinone of preparation method, characterized in that includes: in the reaction container by adding N protection of O - alkyne propanol - aniline, solvent and acid, the reaction is carried

A Convenient Palladium-Catalyzed Carbonylative Synthesis of (E)-3-Benzylidenechroman-4-ones

A convenient palladium-catalyzed carbonylation reaction for the efficient synthesis of (E)-3-benzylidenechroman-4-ones has been developed. Using TFBen as a solid CO source, a range of substituted (E)-3-benzylidenechroman-4-ones were prepared in moderate to good yields with 2-iodophenols and allyl chlorides as the substrates. Additionally, substituted quinolin-4(1H)-ones can also be obtained with 2-iodoaniline as the starting material.

Studies in Antifertility Agents: Part XXVII - Synthesis of 2-Acetyl-3-aryl-5-tosyl-7/8-H (or methoxy)-3,3a,4,5-tetrahydropyrazoloquinolines

N-Tosyl-2,3-dihydro-4-quinolones (12-14), prepared from aniline, m- and p-anisidines by reported procedures, on condensation with araldehydes in the presence of NaOMe give the corresponding 3-arylidene-4-quinolones (15-18).Refluxing of 15-18 with NH2-NH2*H2O in gl.AcOH affords the title compounds, 2-acetyl-3-aryl-5-tosyl-7/8-H (or methoxy)-3,3a,4,5-tetrahydropyrazoloquinolines (19-22).The stereochemistry of the title compounds based on the assignments of C3-H, C3a-H, C4-H2 protons has been studied by PMR decoupling experiments.In preliminary screening, compounds 19 and 22 have been found to prevent pregnancy at 20 mg/kg dose in female albino rats, but are ineffective at lower doses.None of the compounds tested shows any significant pharmacological activity.