76489-36-6

Basic information

• Product Name: 2-hydroxypropane-1,3-diyl bis(3-oxobutanoate)
• CAS NO: 76489-36-6
• Molecular Formula: C₁₁H₁₆O₇
• Molecular Weight: 260.2405
• Mol File: 76489-36-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 395°C at 760 mmHg
• Flash Point: 147.4°C
• Density: 1.244g/cm³
• Vapor Pressure: 7.08E-08mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: 2-hydroxypropane-1,3-diyl bis(3-oxobutanoate)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxypropane-1,3-diyl bis(3-oxobutanoate)(76489-36-6)
• EPA Substance Registry System: 2-hydroxypropane-1,3-diyl bis(3-oxobutanoate)(76489-36-6)

Safety Data

• Hazardous Substances Data: 76489-36-6(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 56-81-5 glycerol 
• 105-45-3 acetoacetic acid methyl ester 
• 141-97-9 ethyl acetoacetate 
• 541-50-4 2-acetoacetic acid 

Relevant articles and documents

Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits.

The promoting effect of glyceryl esters of acetoacetic acid on the rectal absorption of insulin and inulin was studied. A decrease in the serum glucose level was observed in rabbits following the administration of an insulin suppository containing glyceryl-1,3-diacetoacetate (adjuvant II) or 1,2-isopropylideneglycerine-3-acetoacetate (adjuvant IV). The promoting effects of adjuvants II and IV on the rectal absorption of insulin and inulin were suppressed by the addition of calcium and magnesium to the suppository. This indicates that adjuvant interaction with the calcium and magnesium ion located in the rectal membrane is involved in the enhanced absorption of insulin and inulin. Adjuvant release from the suppository formulation in addition to adjuvant lipid solubility were found to be other important factors for enhanced absorption of insulin and inulin.

Selective Catalytic Transesterification, Transthiolesterification, and Protection of Carbonyl Compounds over Natural Kaolinitic Clay

Transesterification and transthiolesterification of β-keto esters with variety of alcohols and thiols and selective protection of carbonyl functions with various protecting groups catalyzed by natural kaolinitic clay are described. The clay has been found to be an efficient catalyst in transesterifying long chain alcohols, unsaturated alcohols, and phenols to give their corresponding β-keto esters in high yields. For the first time, transthiolesterification of β-keto esters with a variety of thiols has been achieved under catalytic conditions. Clay also catalyzes selective transesterification of β-keto esters by primary alcohols in the presence of secondary and tertiary alcohols giving corresponding β-keto esters. A systematic study involving the reactivity of different nucleophiles (alcohols, amines, and thiols) toward β-keto esters is also described. Sterically hindered carbonyl groups as well as α,β-unsaturated carbonyl groups underwent protection without the deconjugation of the double bond. Chemoselective protection of aldehydes in the presence of ketones has also been achieved over natural kaolinitic clay.