76541-44-1

Basic information

• Product Name: 3-(difluoromethyl)pyridine
• Synonyms: 3-(difluoromethyl)pyridine;Pyridine, 3-(difluoromethyl)- (9CI)
• CAS NO: 76541-44-1
• Molecular Formula: C₆H₅F₂N
• Molecular Weight: 129.1074064
• EINECS: 278-487-6
• Product Categories: PYRIDINE
• Mol File: 76541-44-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 42℃/6mm
• Flash Point: 54°(129°F)
• Appearance: /
• Density: 1.242 g/mL at 25 °C
• Vapor Pressure: 2.46mmHg at 25°C
• Refractive Index: n20/D1.462
• PKA: 3.48±0.11(Predicted)
• CAS DataBase Reference: 3-(difluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(difluoromethyl)pyridine(76541-44-1)
• EPA Substance Registry System: 3-(difluoromethyl)pyridine(76541-44-1)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26
• RIDADR: UN 1993C 3 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 76541-44-1(Hazardous Substances Data)

Usage

General Description

3-(difluoromethyl)pyridine, also known as 2,3-difluoropyridine, is a chemical compound with the molecular formula C6H4F2N. It is a colorless liquid with a pungent odor, and is used as an intermediate in the production of various pharmaceuticals and agrochemicals. 3-(difluoromethyl)pyridine is also used as a building block in organic synthesis, and has potential applications in the development of new drugs and crop protection products. It is considered to be a hazardous chemical and should be handled with care, as it can cause irritation to the eyes, skin, and respiratory system. Overall, 3-(difluoromethyl)pyridine is an important chemical with diverse industrial applications, but it requires careful handling and management to ensure safety and environmental protection.

InChI:InChI=1/C6H5F2N/c7-6(8)5-2-1-3-9-4-5/h1-4,6H

Upstream product

• 1120-90-7 3-iodopyridine 
• 626-55-1 3-Bromopyridine 
• 110-86-1 pyridine 
• 381-73-7 Difluoroacetic acid 
• 275818-95-6 sodium difluoromethanesulfinate 
• 3796-23-4 3-(trifluoromethyl)pyridine 
• 500-22-1 3-pyridinecarboxaldehyde 

Downstream Products

• 114468-03-0 3-(1,1-difluoroethyl)pyridine 
• 114468-04-1 3-bromo-5-(difluoromethyl)pyridine 

Relevant articles and documents

Electrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides

This work describes a general strategy for metal-catalyzed cross-coupling of fluoroalkyl radicals with aryl halides under electrochemical conditions. The contradiction between anodic oxidation of fluoroalkyl sulfinates and cathodic reduction of low-valent nickel catalysts can be well addressed by paired electrolysis, allowing for direct introduction of fluorinated functionalities into aromatic systems.

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.