76563-56-9

Basic information

• Product Name: 2,4-DIFLUOROANILINE
• Synonyms: 2,4-Difluoroanilineradical cation
• CAS NO: 76563-56-9
• Molecular Formula: C6H5F2N
• Molecular Weight: 129.11
• Mol File: 76563-56-9.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-DIFLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROANILINE(76563-56-9)
• EPA Substance Registry System: 2,4-DIFLUOROANILINE(76563-56-9)

Safety Data

• Hazardous Substances Data: 76563-56-9(Hazardous Substances Data)

Usage

Derivative of aniline

2,4-Difluoroaniline is a derivative of aniline, with two fluorine atoms attached to the benzene ring.

Common uses

2,4-Difluoroaniline is commonly used in the production of pharmaceuticals, dyes, and agrochemicals.

Building block

2,4-Difluoroaniline is a building block in the synthesis of various organic compounds.

Health hazards

2,4-Difluoroaniline has potential health hazards and should be handled with care.

Safety guidelines

It is important to follow safety guidelines when using 2,4-difluoroaniline in laboratory or industrial settings.

Upstream product

• 446-35-5 2,4-Difluoronitrobenzene 
• 371-40-4 4-fluoroaniline 
• 611-06-3 2,4-dichloronitrobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 121-73-3 3-Nitrochlorobenzene 
• 332-07-0 bis-(4-fluorophenyl)diazene 
• 348-54-9 2-Fluoroaniline 
• 3296-04-6 1-azido-2-fluorobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 3847-58-3 2,4-difluoro-3-chloro-nitrobenzene 
• 36556-48-6 2-Chloro-3,4-difluoroaniline 
• 2613-34-5 2,4-difluoro-3-chloro-aniline 
• 108-70-3 1,3,5-trichlorobenzene 
• 89-69-0 2,4,5-Trichloronitrobenzene 

Downstream Products

• 1933-73-9 bis(2,4-difluorophenylsulfonyl)methane 
• 22494-42-4 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid 
• 1431141-05-7 C₁₈H₁₇F₂N₃O₄S 
• 1431141-08-0 C₁₉H₁₉F₂N₃O₄S 
• 1431141-11-5 C₁₉H₁₉F₂N₃O₄S 
• 860788-24-5 tert-butyl 4-((2,4-difluorophenyl)amino)piperidine-1-carboxylate 
• 145602-64-8 1-(2,4-difluorophenyl)urea 
• 1374748-46-5 methyl 2-(3-((2,4-difluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetate 
• 2272-38-0 6-chloro-N,N'-bis-(2,4-difluoro-phenyl)-[1,3,5]triazine-2,4-diamine 
• 1436865-14-3 C₂₁H₂₅F₂N₃O₂ 
• 919468-45-4 C₂₀H₂₃F₂N₃O₂ 

Relevant articles and documents

Catalytic reduction of nitroarenes with polymeric palladium nanoparticles

An efficient synthesis of Pd nanoparticles in water has been developed using PEG10k as the capping agent. The PEG10k-Pd NPs (2 mol%) efficiently catalyzes reduction of nitro compounds performed in air. The stability of the catalyst allows an extensive recycle in the reduction of nitro compounds. Copyright Taylor & Francis Group, LLC.

Novel preparation method of 2, 4, 5-trifluorophenylacetic acid

The invention discloses a novel preparation method of 2, 4, 5-trifluorophenylacetic acid, which belongs to the technical field of preparation of medical intermediates, and comprises the following preparation steps: carrying out nitration reaction on sulfuric acid and m-dichlorobenzene to obtain an intermediate II; adding the intermediate II, a phase transfer catalyst and potassium fluoride into an aprotic solvent to obtain an intermediate III; performing hydrogenation reaction on the intermediate III to obtain an intermediate IV; carrying out diazotization reaction on the intermediate IV, nitrosyl sulfuric acid and sodium fluoborate to obtain an intermediate V; performing cracking reaction on the intermediate V to obtain an intermediate VI; carrying out reduction reaction on the intermediate VI, and then carrying out bromination reaction on the intermediate VI and liquid bromine to obtain an intermediate VII; subjecting the intermediate VII to a substitution reaction with diethyl malonate, and obtaining 2, 4, 5-trifluorophenylacetic acid after hydrolysis and purification. A novel synthesis route is provided, the problem that technological operation is tedious is solved, the requirements for reaction and operation conditions are low, anhydrous and oxygen-free reaction conditions are not needed, the method is suitable for industrial production, and the yield and purity are greatly improved.

Highly selective hydrogenation of halogenated nitroarenes over Ru/CN nanocomposites by: In situ pyrolysis

A highly chemoselective and recyclable ruthenium catalyst for the hydrogenation of halogenated nitroarenes has been prepared via the simple in situ calcination of a mixture of melamine, glucose and ruthenium trichloride. Superfine Ru particles (2.3 ± 0.3 nm) were obtained and highly dispersed in the nitrogen-doped carbon matrix. The Ru/CN catalyst smoothly transforms a variety of halogenated nitroarenes to the corresponding haloanilines with high intrinsic activity (e.g. TOF = 1333 h-1 for p-chloronitrobenzene) and selectivity of more than 99.6percent. Furthermore, through an analysis of the products in the reaction process, it was concluded that there are two parallel reaction pathways (a direct pathway and an indirect pathway) for the hydrogenation of aromatic nitro compounds over the Ru/CN catalyst, and the direct pathway was proved to be dominant in catalyzing the intermediates. This journal is