76609-16-0

Basic information

• Product Name: 5-CHLORO-2-(4-FLUOROPHENYL)-1H-INDOLE
• Synonyms: 5-CHLORO-2-(4-FLUOROPHENYL)-1H-INDOLE
• CAS NO: 76609-16-0
• Molecular Formula: C₁₄H₉ClFN
• Molecular Weight: 245.68
• Mol File: 76609-16-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-CHLORO-2-(4-FLUOROPHENYL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-(4-FLUOROPHENYL)-1H-INDOLE(76609-16-0)
• EPA Substance Registry System: 5-CHLORO-2-(4-FLUOROPHENYL)-1H-INDOLE(76609-16-0)

Safety Data

• Hazardous Substances Data: 76609-16-0(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 26031-63-0 1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide 
• 106-47-8 4-chloro-aniline 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 146537-22-6 2-((4-chlorophenyl)amino)-1-(4-fluorophenyl)ethanone 
• 63069-48-7 p-chloro-o-iodoaniline 
• 1298069-11-0 4-chloro-2-((4-fluorophenyl)ethynyl)aniline 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 592471-25-5 4-fluoro-N-(4-chloro-2-methylphenyl)benzamide 

Downstream Products

• 1298069-17-6 5-chloro-2-(4-fluorophenyl)-3-((triisopropylsilyl)ethynyl)-1H-indole 
• 1060749-17-8 [5-chloro-2-(4-fluorophenyl)indol-3-yl]glyoxylyl chloride 

Relevant articles and documents

Regioselective Synthesis of 2-Arylindoles via Palladium-Catalyzed Cyclization of Phenylglyoxal and 2-Anilinoacetophenones with Anilines

A versatile route has been developed for the synthesis of 2-arylindoles using a Pd-catalyzed tandem process. Under reductive conditions, different 2-arylindoles were synthesized from phenylglyoxal and aniline. This synthetic methodology involves a tandem reaction of four steps with high regioselectivity. Alternatively, 2-anilinoacetophenones intermediates also can be using to give access to the corresponding 2-arylindoles.

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

The Au(III)-catalyzed cyclization of 2-alkynylanilines was combined in a one-pot procedure with the Au(I)-catalyzed C3-selective direct alkynylation of indoles using the benziodoxolone reagent TIPS-EBX to give a mild, easy and straightforward entry to 2-substituted-3-alkynylindoles. The reaction can be applied to unprotected anilines, was tolerant to functional groups and easy to carry out (RT, and requires neither an inert atmosphere nor special solvents).

SYNTHESIS AND MASS SPECTRAL STUDIES OF FLUORINE CONTAINING 5a, 7b, 12a, 14b-TETRAHYDROBISINDOLO BENZO DIFURANS

2:1 Cycloadducts (-H2) are formed when various fluorinated 2-arylindoles are stirred with p-benzoquinone in acidic medium and are identified as dimers of the type 5a, 7b, 12a, 14b-tetrahydrobisindolo benzo difurans.All the synthesized compounds have been characterized by their analytical and spectral (IR, PMR, 19F NMR and Mass) data.