76653-14-0

Basic information

• Product Name: 2-(4-METHOXYPHENYL)ETHANESULFONYL CHLORIDE
• Synonyms: 2-(4-METHOXYPHENYL)ETHANESULFONYL CHLORIDE;OTAVA-BB 1038773
• CAS NO: 76653-14-0
• Molecular Formula: C₉H₁₁ClO₃S
• Molecular Weight: 234.7
• Mol File: 76653-14-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 339.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.313±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-METHOXYPHENYL)ETHANESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXYPHENYL)ETHANESULFONYL CHLORIDE(76653-14-0)
• EPA Substance Registry System: 2-(4-METHOXYPHENYL)ETHANESULFONYL CHLORIDE(76653-14-0)

Safety Data

• Hazardous Substances Data: 76653-14-0(Hazardous Substances Data)

Usage

Structure

Contains a methoxyphenyl group attached to an ethanesulfonyl chloride moiety

Reactivity

Highly reactive and corrosive

Usage

Commonly used in organic synthesis as a reagent for introducing the sulfonyl chloride group into aromatic compounds, and as a building block in the synthesis of pharmaceuticals and agrochemicals

Handling precautions

Should be handled with care and used in a well-ventilated environment due to its reactivity and corrosiveness.

Upstream product

• 35731-82-9 sodium 4-methoxy-β-phenethylsulfonate 
• 14425-64-0 4-methoxyphenethyl bromide 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 

Downstream Products

• 76653-00-4 4-methoxy-β-phenethylsulfonyl azide 
• 76653-15-1 4-methoxy-β-phenethylsulfonamide 
• 1433543-71-5 N-hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide 
• 1433545-75-5 C₁₂H₁₇NO₅S 
• 1584657-73-7 2-(4-methoxyphenyl)-N-(2,4,6-trimethoxyphenyl)ethanesulfonamide 

Relevant articles and documents

Discovery of a new class of potent MMP inhibitors by structure-based optimization of the arylsulfonamide scaffold

A new class of potent matrix metalloproteinase (MMP) inhibitors designed by structure-based optimization of the well-known arylsulfonamide scaffold is presented. Molecules show an ethylene linker connecting the sulfonamide group with the P1' aromatic portion and a D-proline residue bearing the zinc-binding group. The affinity improvement provided by these modifications led us to discover a nanomolar MMP inhibitor bearing a carboxylate moiety as zinc-binding group, which might be a promising lead molecule. Notably, a significant selectivity for MMP-8, MMP-12, and MMP-13 was observed with respect to MMP-1 and MMP-7.