76686-83-4

Basic information

• Product Name: 1H-1,2,4-Triazole-1-propanenitrile(9CI)
• Synonyms: 1H-1,2,4-Triazole-1-propanenitrile(9CI);3-(1H-1,2,4-TRIAZOL-1-YL)PROPANENITRILE
• CAS NO: 76686-83-4
• Molecular Formula: C₅H₆N₄
• Molecular Weight: 122.13
• Product Categories: TRIAZOLE
• Mol File: 76686-83-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-1,2,4-Triazole-1-propanenitrile(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole-1-propanenitrile(9CI)(76686-83-4)
• EPA Substance Registry System: 1H-1,2,4-Triazole-1-propanenitrile(9CI)(76686-83-4)

Safety Data

• Hazardous Substances Data: 76686-83-4(Hazardous Substances Data)

Usage

Uses

3-(1H-1,2,4-Triazol-1-yl)propanenitrile acts as a reagent in the synthesis of hydroxyphenacyl azoles and related azolium derivatives as antifugal agents.

Upstream product

• 288-88-0 1,2,4-Triazole 
• 107-13-1 acrylonitrile 

Downstream Products

• 1384463-32-4 Br^(1-)*C₂₁H₁₇Cl₂N₄O⁽¹⁺⁾ 
• 1384463-55-1 Br^(1-)*C₂₁H₁₅Cl₂N₄⁽¹⁺⁾ 
• 1384463-54-0 Br^(1-)*C₂₁H₁₇N₄⁽¹⁺⁾ 
• 1384463-30-2 Br^(1-)*C₂₁H₁₉N₄O⁽¹⁺⁾ 
• 100468-26-6 N-(3-[1,2,4]Triazol-1-yl-propyl)-3-trifluoromethyl-benzamide 
• 100467-99-0 Biphenyl-2-carboxylic acid (3-[1,2,4]triazol-1-yl-propyl)-amide 
• 100468-27-7 2-(3-Chloro-phenyl)-N-(3-[1,2,4]triazol-1-yl-propyl)-acetamide 
• 100468-25-5 2-Fluoro-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100467-94-5 3,4,5-trimethoxy-N-[3-(1H-1,2,4-triazol-1-yl)propyl]benzamide 
• 100467-96-7 4-Acetylamino-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100467-95-6 4-Benzoyl-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100467-98-9 3-Nitro-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100467-93-4 4-Butoxy-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100468-13-1 2-(4-Chloro-phenoxy)-N-(3-[1,2,4]triazol-1-yl-propyl)-acetamide 

Relevant articles and documents

Non-catalytic addition of 1,2,4-triazole to nucleophilic and electrophilic alkenes

Non-catalytic addition of 1,2,4-triazole to vinyl ethers and esters occurs on heating (65-175°C, 4-20 h) to give Markovnikov adducts (yield 30-100%). Electron-deficient alkenes (acrylonitrile, acrylic acid, 4-phenyl-3-buten-2-one) react with 1,2,4-triazole (78-190°C, 4-20 h) to give anti-Markovnikov adducts in yields of 45-83%.

A general design platform for ionic liquid ions based on bridged multi-heterocycles with flexible symmetry and charge

A conceptual design platform for new ionic liquids with variable heterocycles, bridges, symmetry, and charge was developed using simple alkylation, click, and ionic liquid chemistries and demonstrated with 1-(2-(5-tetrazolidyl)ethyl)-3-(5-1H-tetrazolyl)methylimidazolium and its conversion into room-temperature ionic liquids as cation or as anion.

AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS

The present invention is related to azole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such azole derivatives. Said azole derivatives are modulators of the protein kinase signalling pathways, particularly the one involving c-Jun N-terminal kinase and/or Glycogen Kinase Synthase 3. The present invention is furthermore related to novel azole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1 -C6 alkyl; A is 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group.