767-15-7

Basic information

• Product Name: 2-Amino-4,6-dimethylpyrimidine
• Synonyms: ,6-Dimethyl-2-aminopyrimidine;,6-Dimethyl-pyrimidin-2-ylamine;2-amino-4,6-dimethyl-pyrimidin;2-Amino-4,6-dimethypyrimidine;2-Pyrimidinamine,4,6-dimethyl-;4,6-dimethyl-2-aminopyrimidine;4,6-dimethyl-2-pyrimidinamin;4,6-Dimethyl-2-pyrimidinamine
• CAS NO: 767-15-7
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• EINECS: 212-181-5
• Product Categories: PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Amines;Pyrazines, Pyrimidines & Pyridazines;Chemical Amines;Pyrimidines;Bases & Related Reagents;Heterocycles;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Heterocycle-Pyrimidine series
• Mol File: 767-15-7.mol
• Article Data: 37

Chemical Properties

• Melting Point: 151-153 °C(lit.)
• Boiling Point: 219.27°C (rough estimate)
• Flash Point: 156.7 °C
• Appearance: White to beige/Crystalline Powder
• Density: 1.1097 (rough estimate)
• Vapor Pressure: 0.00166mmHg at 25°C
• Refractive Index: 1.5589 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 5.11±0.10(Predicted)
• BRN: 110735
• CAS DataBase Reference: 2-Amino-4,6-dimethylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4,6-dimethylpyrimidine(767-15-7)
• EPA Substance Registry System: 2-Amino-4,6-dimethylpyrimidine(767-15-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• RTECS: UV6260496
• TSCA: Yes
• Hazardous Substances Data: 767-15-7(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Powder

Uses

2-Amino-4,6-dimethylpyrimidine is a bioactive compound.

Purification Methods

Recrystallisation from water gives the pyrimidine with m 197o, but recrystallisation from acetone gives m 153o. [Beilstein 25 III/IV 2205.]

InChI:InChI=1/C6H9N3/c1-4-3-5(2)9-6(7)8-4/h3H,1-2H3,(H2,7,8,9)

Synthetic route

guanidine hydrochloride (50-01-1) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With potassium carbonate for 0.0833333h; microwave irradiation;	96%
With potassium carbonate In water at 100℃; for 0.0833333h; Microwave irradiation;	85%
With sodium carbonate In water at 60℃; for 0.5h; Reagent/catalyst; Time; Sonication;	75%
With potassium carbonate In ethanol	74%
With potassium carbonate In water at 40℃; for 24h;

guanidine nitrate (506-93-4) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With potassium carbonate In water at 80℃; for 7h;	96%
With potassium carbonate In water at 80℃; for 7h;	96%
Stage #1: guanidine nitrate; acetylacetone In water at 20℃; for 0.5h; Stage #2: With sodium carbonate In water for 3h; Reflux;	69.5%
With sodium acetate at 120℃;
With sodium carbonate In water at 80℃; for 4h;	52.3 g

guanidinium sulfate (594-14-9) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With sodium carbonate In water at 100℃; Product distribution / selectivity;	95%

guanidinium sulfate (646-34-4) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With sodium carbonate In water at 100℃; Inert atmosphere;	95%
With sodium carbonate In water at 100℃; for 24h; Inert atmosphere;	95%

4-Aminopent-3-en-2-one (1118-66-7) + CYANAMID (420-04-2) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
In water for 1h; Heating;	93%

guanidine nitrate (113-00-8) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
In ethanol for 8h; Reflux;	85.2%
In dimethylsulfoxide-d6 at 22 - 28℃; Mechanism; determined of intermedier by 13C nmr;

2-amino-6-methyl-4-chloropyrimidine (5600-21-5) + Trimethylboroxine (823-96-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With C70H40Cl2F68N2O6Pd2; tetrabutylammomium bromide; potassium carbonate In water at 140℃; for 0.633333h; Suzuki-Miyaura reaction; Microwave irradiation;	85%

(Z)-4-phenylthiopent-3-en-2-one (70769-79-8) + guanidine nitrate (113-00-8) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With sodium hydroxide In ethanol for 6h; Heating;	73%

guanidine hydrochloride salt + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
In N,N-dimethyl-formamide at 80℃;	60%

CYANAMID (420-04-2) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-amino-3-penten-2-one (1118-66-7)

Conditions	Yield
With potassium carbonate In water for 8h;	A 43% B 3%

CYANAMID (420-04-2) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-<(aminocarbonyl)imino>-2-penten-2-ol (91606-59-6) + urea*2-hydroxy-4,6-dimethylpyrimidine (87773-24-8)

Conditions	Yield
In water for 22h;	A n/a B 23% C n/a
In water for 168h;	A n/a B 23% C n/a

3-acetylpentane-2,4-dione (815-68-9) + guanidine hydrochloride (50-01-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With sodium ethanolate In ethanol 1.) room temperature, 2 h, 2.) reflux, 2 h;	18%
With sodium ethanolate In ethanol for 2h; Heating;	18%

4-azido-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
In methanol Irradiation;	15%

2-chloro-4,6-dimethylpyrimidine (4472-44-0) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With ethanol; ammonia at 100℃; im Rohr;
With ammonium hydroxide In ethanol at 45℃;

sulfadimesine (57-68-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
beim Erhitzen der Base sowie des Natrium-Salzes ueber den Schmelzpunkt;
Multi-step reaction with 2 steps 1: 1.) NaNO2, 2M HCl, 2.) NaN3 / 1.) H2O, 0 deg C 2: 15 percent / methanol / Irradiation View Scheme
In water Quantum yield; UV-irradiation;

guanidine hydrogen carbonate (124-46-9, 20734-13-8, 100224-74-6, 593-85-1) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

diguanidine carbonate (593-85-1) + acetylacetone (123-54-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

2-Amino-4,6-dimethylpyrimidine 1-oxide (19250-33-0) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With hydrogen; palladium on activated charcoal for 1h; Pressure (range begins): 45 ; Yield given;

4-Dimethylamino-1-(4,6-dimethyl-pyrimidin-2-yl)-3-phenyl-[1,3]diazetidin-2-one → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
In diethylene glycol dimethyl ether for 1h; Heating;

1-cyano-4.6-dimethyl-pyrimidone-(2)-imide → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With sulfuric acid
With hydrogenchloride
With hydrogenchloride at 125℃; im Rohr;

2-chloro-4,6-dimethylpyrimidine (4472-44-0) + ammonia (7664-41-7) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
at 100℃;

acetylacetone (123-54-6) + guanidine salt → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
With sodium hydroxide
With sodium carbonate
With sulfuric acid

CYANAMID (420-04-2) + (Z)-4-Amino-1-trimethylsilanyl-pent-3-en-2-one (403815-86-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
In ethanol Heating;

3-methyl-5-[(trimethylsilyl)methyl]isoxazole (75632-83-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / Raney nickel / ethanol / 24 h / 20 °C / 20685.9 Torr 2: ethanol / Heating View Scheme

2-(N,N-dimethylaminomethyleneamino)-4,6-dimethylpyrimidine (51567-39-6) → 2-Amino-4,6-dimethylpyrimidine (767-15-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / CH2Cl2 / Ambient temperature 2: bis-(2-methoxy-ethyl) ether / 1 h / Heating View Scheme

Pyrimethanil (53112-28-0) → 2-Amino-4,6-dimethylpyrimidine (767-15-7) + 1,3-dimethylpyrimido<1,2-a>benzimidazole (25513-98-8) + C9H11N3O (1449337-59-0) + C12H13N3 (1449337-60-3) + C12H11N3O (1449337-61-4) + C12H13N3O (1449337-62-5) + C12H13N3O + C12H13N3O + aniline (62-53-3)

Conditions	Yield
With water In acetonitrile at 25℃; for 3h; Time; UV-irradiation; Sonication; Inert atmosphere;

...Expand

sulfadimesine (57-68-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7) + aniline (62-53-3) + 4-aminobenzene sulfonic acid (121-57-3) + phenol (108-95-2)

Conditions	Yield
With iron(II) sulfate In water at 20℃; Kinetics; Concentration; Reagent/catalyst; Sonication; Inert atmosphere;

sulfadimesine (57-68-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7) + N-(4,6-dimethyl-2-pyrimidine)-1,4-phenylenediamine (81261-93-0) + carbon dioxide (124-38-9)

Conditions	Yield
With graphitic carbon nitride; dihydrogen peroxide In water for 1.5h; pH=6.9; Kinetics; Reagent/catalyst; Irradiation;

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 2-methoxycarbonylbenzenesulfonyl chloride (26638-43-7) → Sulfometuron methyl (74222-97-2)

Conditions	Yield
In acetonitrile	98%

indole (120-72-9) + 2-Amino-4,6-dimethylpyrimidine (767-15-7) + 2-chloro-benzaldehyde (89-98-5) → N-[(1H-indole-3-yl)(2-chlorophenyl)methyl]-4,6-dimethylpyrimidine-2-amine (1258955-60-0)

Conditions	Yield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 0.416667h; Reagent/catalyst; Green chemistry;	98%
at 80℃; for 4h;	87%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 2-(2-Chloroethoxy)phenoxysulfonyl isocyanate → sodium ((2-(2-chloroethoxy)phenoxy)sulfonyl)((4,6-dimethylpyrimidin-2-yl) carbamoyl)amide

Conditions	Yield
Stage #1: 2-Amino-4,6-dimethylpyrimidine; 2-(2-Chloroethoxy)phenoxysulfonyl isocyanate In acetonitrile at 20℃; for 24h; Stage #2: With sodium hydrogencarbonate	97%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + Benzoyl isothiocyanate (532-55-8) → 3-benzoyl-1-(4,6-dimethylpyrimidin-2-yl)thiourea (121087-84-1)

Conditions	Yield
In acetone for 0.5h; Heating;	95%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + ibuprofen (15687-27-1) → N-(4,6-dimethyl-pyrimidin-2-yl)-2-(4-isobutyl-phenyl)-propionamide

Conditions	Yield
Stage #1: ibuprofen With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 0.5h; Stage #2: 2-Amino-4,6-dimethylpyrimidine In dichloromethane for 72h; Heating;	95%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-(diphenylamino)benzaldehyde (4181-05-9) → 2-amino-4,6-bis[(4-N,N-diphenylamino)styryl]pyrimidine

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water for 0.5h; Heating;	94%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 2-phenoxyacetic acid (122-59-8) → C14H15N3O2 (349542-30-9)

Conditions	Yield
With silica gel In toluene Reflux;	94%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + N-(2,6-dimethoxy pyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide → N-(2,6-dimethoxypyrimidin-4-yl)-4-[3-(4,6-dimethylpyrimidin-2-yl)thioureido]benzenesulfonamide

Conditions	Yield
With triethylamine In 1,4-dioxane for 1h; Reflux;	94%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-(diphenylamino)benzaldehyde (4181-05-9) → 2-amino-4,6-bis-[(4-N,N′-diphenylamino)styryl]pyrimidine

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide	94%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-bromo-benzaldehyde (1122-91-4) + β-naphthol (135-19-3) → 1-[(4-bromo-phenyl)-(4,6-dimethyl-pyrimidin-2-ylamino)-methyl]-naphthalen-2-ol

Conditions	Yield
With magnesium sulphate trihydrate In neat (no solvent) at 100℃; for 0.216667h; Green chemistry;	94%

indole (120-72-9) + 2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-methyl-benzaldehyde (104-87-0) → N-((1H-indol-3-yl)(p-tolyl)methyl)-2-amino-4,6-dimethylpyrimidine (1555971-51-1)

Conditions	Yield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 0.416667h; Reagent/catalyst; Green chemistry;	93%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + C10H8INO6S → sodium ((4,6-dimethylpyrimidin-2-yl)carbamoyl)((2-((2-iodoethoxy)carbonyl)phenoxy)sulfonyl)amide

Conditions	Yield
Stage #1: 2-Amino-4,6-dimethylpyrimidine; C10H8INO6S In acetonitrile at 20℃; for 24h; Stage #2: With sodium hydrogencarbonate	93%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-methyl-benzaldehyde (104-87-0) + β-naphthol (135-19-3) → 1-[(4,6-dimethyl-pyrimidin-2-ylamino)-(4-methylphenyl)-methyl]-naphthalen-2-ol

Conditions	Yield
With magnesium sulphate trihydrate In neat (no solvent) at 100℃; for 0.3h; Green chemistry;	93%

indole (120-72-9) + 2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-nitrobenzaldehdye (555-16-8) → N-[(1H-indole-3-yl)(4-nitrophenyl)methyl]-4,6-dimethylpyrimidine-2-amine (1258955-59-7)

Conditions	Yield
at 80℃; for 5h;	92%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 0.916667h; Reagent/catalyst; Green chemistry;	87%

indole (120-72-9) + 2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-bromo-benzaldehyde (1122-91-4) → N-[(1H-indole-3-yl)(4-bromophenyl)methyl]-4,6-dimethylpyrimidine-2-amine (1258955-57-5)

Conditions	Yield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide at 20℃; for 0.333333h; Reagent/catalyst; Green chemistry;	92%
at 80℃; for 4h;	88%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + salicylaldehyde (90-02-8) + β-naphthol (135-19-3) → 1-(2-hydroxyphenyl(2-(4,6-dimethylpyrimidinyl)amino)methyl)naphthalene-2-ol (1393090-63-5)

Conditions	Yield
at 80℃; for 0.5h; Mannich type reaction; neat (no solvent);	92%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + orthoformic acid triethyl ester (122-51-0) + 2,3-naphthalenediol (92-44-4) → C17H15N3O2

Conditions	Yield
With formic acid In water at 110℃; for 0.333333h; Green chemistry;	92%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + C11H11NO6S → sodium ((4,6-dimethylpyrimidin-2-yl)carbamoyl)((2-(propoxycarbonyl) phenoxy)sulfonyl)amide

Conditions	Yield
Stage #1: 2-Amino-4,6-dimethylpyrimidine; C11H11NO6S In acetonitrile at 20℃; for 24h; Stage #2: With sodium hydrogencarbonate	92%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-methoxy-benzaldehyde (123-11-5) + β-naphthol (135-19-3) → 1-[(4,6-dimethyl-pyrimidin-2-ylamino)-(4-methoxyphenyl)-methyl]-naphthalen-2-ol

Conditions	Yield
With magnesium sulphate trihydrate In neat (no solvent) at 100℃; for 0.333333h; Green chemistry;	92%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 4-chlorobenzaldehyde (104-88-1) + β-naphthol (135-19-3) → 1-[(4-chloro-phenyl)-(4,6-dimethyl-pyrimidin-2-ylamino)-methyl]-naphthalen-2-ol

Conditions	Yield
With magnesium sulphate trihydrate In neat (no solvent) at 100℃; for 0.2h; Green chemistry;	92%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + m-bromobenzoic aldehyde (3132-99-8) + β-naphthol (135-19-3) → 1-[(3-bromo-phenyl)-(4,6-dimethyl-pyrimidin-2-ylamino)-methyl]-naphthalen-2-ol

Conditions	Yield
With magnesium sulphate trihydrate In neat (no solvent) at 100℃; for 0.25h; Green chemistry;	92%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 2,7-Dihydroxynaphthalene (582-17-2) + salicylaldehyde (90-02-8) → 1-(2-hydroxyphenyl(2-(4,6-dimethylpyrimidinyl)amino)methyl)naphthalene-2,7-diol (1393090-70-4)

Conditions	Yield
at 80℃; Mannich type reaction; neat (no solvent);	91%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + 2,7-Dihydroxynaphthalene (582-17-2) + terephthalaldehyde, (623-27-8) → 1,4-bis[(4,6-dimethylpyrimidin-2-ylamino)(2,7-dihydroxynaphthalene-1-yl)methyl]benzene (1447758-44-2)

Conditions	Yield
With formic acid In neat (no solvent) at 80℃; for 0.25h; Mannich Aminomethylation; Green chemistry;	91%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + m-bromobenzoic aldehyde (3132-99-8) + 2,3-naphthalenediol (92-44-4) → 1,4-bis((4,6-dimethylpyrimidin-2-ylamino)(3-bromophenyl)methyl)naphthalene-2,3-diol

Conditions	Yield
With formic acid In neat (no solvent) at 80℃; for 0.833333h; Betti Reaction; Green chemistry;	91%

2-Amino-4,6-dimethylpyrimidine (767-15-7) + benzaldehyde (100-52-7) + β-naphthol (135-19-3) → 1-[(4,6-dimethyl-pyrimidin-2-ylamino)-phenylmethyl]-naphthalen-2-ol

Conditions	Yield
With magnesium sulphate trihydrate In neat (no solvent) at 100℃; for 0.25h; Catalytic behavior; Temperature; Reagent/catalyst; Green chemistry;	91%

Upstream product

• 1118-66-7 4-Aminopent-3-en-2-one 
• 420-04-2 CYANAMID 
• 815-68-9 3-acetylpentane-2,4-dione 
• 50-01-1 guanidine hydrochloride 
• 70769-79-8 (Z)-4-phenylthiopent-3-en-2-one 
• 113-00-8 guanidine nitrate 
• 123-54-6 acetylacetone 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 7664-41-7 ammonia 
• 53112-28-0 Pyrimethanil 
• 57-68-1 sulfadimesine 
• 5600-21-5 2-amino-6-methyl-4-chloropyrimidine 
• 823-96-1 Trimethylboroxine 
• 646-34-4 guanidinium sulfate 

Downstream Products

• 7510-86-3 sulfanilic acid-(5-chloro-4,6-dimethyl-pyrimidin-2-ylamide) 
• 99722-65-3 2-[(2,6-dichlorophenyl)-(1,2,4-triazol-1-yl)methyl]-amino-4,6-dimethylpyrimidine 
• 1024583-58-1 C₂₉H₂₃F₃N₆O₂S 
• 446839-32-3 1-amino-4,6-dimethyl-1H-pyrimidin-2-ylidene-amnnoniunn 2,4,6-trinnethyl-benzenesulfonate 
• 1207180-94-6 C₁₄H₁₄N₄OS 
• 521300-52-7 C₁₈H₂₁N₃O₄ 
• 349542-30-9 C₁₄H₁₅N₃O₂ 
• 1311288-90-0 5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine 
• 1311288-93-3 5-(benzyloxy)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidin-2-ylamine 
• 1311288-96-6 10-(5-(benzyloxy)-2-(dimethylamino)-6-methylpyrimidin-4-yl)decan-1-ol 
• 1330767-04-8 5-(benzyloxy)-2-chloro-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine 
• 1330767-05-9 5-(benzyloxy)-2-methoxy-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine 
• 1330767-06-0 5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-6-pentylpyrimidine 
• 1330767-07-1 5-(benzyloxy)-4-methyl-6-pentylpyrimidin-2-amine 

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Sulfamethazine (SMZ) is an important sulfonamide antibiotic. Although the concentration in the environment is small, it is harmful. The drug residues can be transferred, transformed or accumulated, affecting the growth of animals and plants. In this study, the integrated fixed-film activated sludge membrane bioreactor (IFAS-MBR) were constructed to investigate the performance and degradation mechanism of SMZ. The addition of SMZ had a significant impact on the removal of the chemical oxygen demand (COD) and ammonia nitrogen (NH4 +-N). The optimal operating conditions were hydraulic retention time (HRT) at 10 h and solid retention time (SRT) at 80 d, respectively. On this basis, the effects of different SMZ concentrations on nutrient removal, degradation, and sludge characteristics were compared. The removal efficiency of SMZ increased with the increase of SMZ concentration. The maximum removal rate was as high as 87%. The SMZ dosage also had an obvious effect on sludge characteristics. As the SMZ concentration increased, the extracellular polymer substances (EPS) concentration and the membrane resistance both decreased, which were beneficial for the reduction of membrane fouling. Finally, seven kinds of SMZ biodegradation intermediates were identified, and the possible degradation pathways were speculated. The microbial community results showed that the microbial diversity and richness in the reactor decreased after adding SMZ to the influent. The relative abundance of Bacteroidetes, Actinobacteria, Saccharibacteria and Nitrospirae increased at the phylum level. Sphingobacteria and Betaproteobacteria became dominant species at the class level. The relative abundance of norank-p-Saccharibacteria and Nitrospirae increased significantly, and norank-p-Saccharibacteria may be the dominant bacteria for SMZ degradation.

Imidazo[4,5-c]pyridine derivative and application thereof

The invention relates to a novel imidazo[4,5-c]pyridine derivative represented by a general formula I, and pharmaceutically acceptable salts, solvates or prodrugs of the novel imidazo[4,5-c]pyridine derivative, wherein the substituent R and R' are defined as in the specification. The invention also relates to an effect of the compound represented by the general formula I in inhibiting an NS5B RNA-dependent RNA polymerase (NS5B polymerase for short) which is necessary in a replication process of hepatitis c virus, also relates to an application of the compound, and pharmaceutically acceptable salts, hydrates or prodrugs of the compound in preparation of medicines for treating viral diseases, and especially relates to an application in preparation of medicines for treating and/or preventinghepatitis c.