767-79-3

Basic information

• Product Name: 2,4,5,6-Tetrafluoropyrimidine
• Synonyms: 2,4,5,6-Tetrafluoropyrimidine;tetrafluoropyriMidine;2,4,5,6-Tetrafluoropyrimidine, 2,4,5,6-Tetrafluoro-1,3-diazine;Pyrimidine, tetrafluoro-
• CAS NO: 767-79-3
• Molecular Formula: C₄F₄N₂
• Molecular Weight: 152
• Mol File: 767-79-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 83℃
• Flash Point: 78.5°C
• Appearance: /
• Density: 1.639g/cm³
• Vapor Pressure: 0.346mmHg at 25°C
• Refractive Index: 1.398
• CAS DataBase Reference: 2,4,5,6-Tetrafluoropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5,6-Tetrafluoropyrimidine(767-79-3)
• EPA Substance Registry System: 2,4,5,6-Tetrafluoropyrimidine(767-79-3)

Safety Data

• Hazard Codes: C,Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 767-79-3(Hazardous Substances Data)

Usage

General Description

2,4,5,6-Tetrafluoropyrimidine is a chemical compound with the molecular formula C4H1F4N2. It is a member of the pyrimidine family, which is a group of organic compounds that includes the nitrogenous base found in DNA and RNA. 2,4,5,6-Tetrafluoropyrimidine is a heterocyclic compound, meaning it contains atoms of at least two different elements in its ring structure. This chemical is used in organic synthesis and pharmaceutical research as a building block for creating new compounds with potential medicinal applications. Its specific properties and potential uses in drug development are areas of ongoing research and investigation.

InChI:InChI=1/C4F4N2/c5-1-2(6)9-4(8)10-3(1)7

Upstream product

• 1780-40-1 2,4,5,6-tetrachloropyrimidine 
• 7627-80-7 tetrafluoropyridazine 
• 55827-89-9 perfluoro-4,5-di-s-butylpyridazine 
• 696-82-2 2,4,6-trifluoropyrimidine 

Downstream Products

• 93832-50-9 2,5,6-trifluoro-4-(2,4,6-trimethylphenylazo)pyrimidine 
• 697-83-6 2,4,6-trifluoro-5-chloropyrimidine 
• 17573-83-0 2,5,6-trifluoro-N-phenylpyrimidin-4-amine 

Relevant articles and documents

Polyhalogenoheterocyclic Compounds. Part 23. Mechanism of Thermal Rearrangements of Perfluoropyridazine and Perfluoroalkylpyridazines

Rearrangement of perfluoro-4,5-di-s-butylpyridazine (4) to a mixture of perfluoro-4,5-di-s-butylpyrimidine (13) and -2,5-di-s-butylpyrazine (20), occurs at 300 deg C, in a sealed tube.Cross-over experiments between various fluorinated pyridazine derivatives and, also, doubly 15N-labelled derivatives, rule out any rearrangement mechanism involving a cycloaddition process.Compound (4) and other fluorinated compounds act as promoters for the rearrangement of various fluorinated pyridazine derivatives and this process is now most reasonably regarded as a free-radical promoted formation of valence isomers.

Process for the preparation of 5-fluoropyrimidines

5-Fluoropyrimidines are obtained in an advantageous manner from halogenated 5-unsubstituted pyrimidines, when these are reacted with elemental fluorine in the presence of a solvent.

Detection of a Transient after Flash Photolysis of Perfluorinated Diazines in the Gas Phase

Mass spectrometric evidence indicates that flash photolysis of tetrafluoro-pyridazine, -pyrimidine, and -pyrazine produced short-lived isomers with a fulvene-type structure; the values of the rate constants for the formation and decay are given.