768-05-8Relevant articles and documents
A discrete dysprosium trigonal prism showing single-molecule magnet behaviour
Tian, Haiquan,Wang, Min,Zhao, Lang,Guo, Yun-Nan,Guo, Yang,Tang, Jinkui,Liu, Zhiliang
, p. 442 - 445 (2012)
A magnetic personality: A unique dysprosium trigonal prism with a new polydentate Schiff-base ligand behaves as a single molecule magnet (SMM), which may stimulate further investigations into the relaxation dynamics of SMMs with different topologies (see
A chromone based Schiff base: An efficient colorimetric sensor for specific detection of Cu (II) ion in real water samples
Tomer, Nisha,Goel, Apurva,Ghule, Vikas D.,Malhotra, Rajesh
, (2021)
A new chromone based Schiff base ligand L was synthesized by the condensation of 3-formyl chromone and pyrazine-2-carbohydrazide as a colorimetric probe to detect Cu (II) ions selectively. An instant visual colour change from colourless to yellow was obtained on addition of Cu2+ ions to the probe L solution, while other metal ions found ineffective. The ligand L was characterized by 1H NMR, FTIR and HRMS spectral techniques. UV-Visible spectroscopic technique was used to study the sensing ability of probe L for copper ions above other metal ions. The Job's plot obtained from absorption studies and HRMS data confirmed that the Cu2+ ions bind with ligand L in 1:1 stoichiometric ratio. DFT computations were also supported the binding framework between L and Cu (II) ions. The LOD value and the association constant were obtained 3.9 × 10?7 M and 2.3 × 105 M?1 respectively, via Benesi-Hildebrand equation. Selectivity of L towards Cu2+ ions was also studied and it was found that the probe L worked specifically for copper ions without any considerable influence of other intruding metal ions. In addition, in real water samples, the ligand L was fully implemented for identification and quantification of Cu2+ ions.
A chromone hydrazide Schiff base fluorescence probe with high selectivity and sensitivity for the detection and discrimination of human serum albumin (HSA) and bovine serum albumin (BSA)
Yan, Xiao-Jing,Li, Zhe,Liu, Hai-Bo,Wang, Zhi-Gang,Fan, Jing,Xie, Cheng-Zhi,Li, Qing-Zhong,Xu, Jing-Yuan
, (2021/10/12)
The discrimination and identification of human serum albumin (HSA) and bovine serum albumin (BSA) is very important, which is due to the vital roles of two SAs in biological and pharmaceutical research. Based on structural screening and docking calculation from a series of homologues, a coumarin Schiff base fluorescent probe 3-hydroxy-N′-((4-oxo-4H-chromen-3-yl)methylene)-2-naphthohydrazide (HCNH) has been designed and synthesized, which could effectively discriminate HSA and BSA. The probe HCNH exhibited superior sensitivity toward HSA and BSA with the detection limits of 10.62 nM and 16.03 nM in PBS solution, respectively. The binding mechanism of HCNH with SAs was studied by Job's plot analysis, SA destruction and displacement assay. Molecular docking and DFT methods were utilized to provide deep insight into the spatial conformation change of HCNH and binding sites in HSA/BSA. The conformation of HCNH was significantly influenced by the microenvironment provided by HSA and BSA, therefore its fluorescence emission was affected correspondingly. Non-toxic probe HCNH could be successfully used for fluorescence bio-imaging of HSA in cancer cells, which is significantly different from normal cells and favors the application in medical diagnosis.
Pyrazinederived 1,2,3-triazole linked silanes and their magnetic nanoparticles for the colorimetric and fluorimetric dual sensing of Cu2+ ions
Devi, Anita,Diksha,Kaur, Jashandeep,Mohit,Priyanka,Saini, Anamika,Singh, Gurjaspreet,Suman,Sushma
, (2022/03/16)
In this article, pyrazinebased 1,2,3-triazole linked organosilanes have been synthesized and characterized with techniques like 1H, 13C NMR spectroscopy and mass spectrometry. The synthesized compound 6b (PTSR)could selectively and sensitively recognize Cu2+ ionswhereas the interference from other metal ions was negligible. The 6(b) behaves as reversible sensor for Cu2+ions. The fluorescence response of 6(b) toward Cu2+ions showed a significant fluorescence quenching. Further,the sensing application was enhanced by the immobilization of organic moiety on the magnetic silicasurface. The adsorption of organosilaneis confirmed by various techniques such as FT-IR, EDX, XRD, TGA, SEM, HR-TEM, DLS. The hybrid magnetic nanoparticles (HNPs)are found to be more sensitive for Cu2+ ions with low LOD as compare to 6(b)i.e. 2.7 × 10?6 M. In addition, the synthesized alkynes and silanes were examined fordrug-likeness profile by using online available toolkits like MOLINSPIRATION and ADMET.
