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7689-3-4

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General Description

Camptothecin is a cytotoxic quinoline alkaloid compound that has been widely studied for its potential as an anti-cancer drug. It works by inhibiting the enzyme topoisomerase I, which is involved in the unwinding of DNA during replication. This inhibition leads to the accumulation of DNA breaks and ultimately cell death. Camptothecin has shown promising results in the treatment of various cancers, including ovarian, colorectal, and lung cancer. However, its clinical use has been limited due to its low solubility and poor stability in the body. Efforts are currently underway to develop analogs and derivatives of camptothecin with improved pharmacokinetic properties for more effective cancer treatment.
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