770-30-9

Basic information

• Product Name: 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
• Synonyms: ART-CHEM-BB B022140;BUTTPARK 27\08-64;AKOS BBS-00005292;AKOS UB-20020;AKOS B022140;4-AMINO-5-CYANO-2-(METHYLTHIO)PYRIMIDINE;4-AMINO-2-(METHYLSULFANYL)PYRIMIDINE-5-CARBONITRILE;4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
• CAS NO: 770-30-9
• Molecular Formula: C₆H₆N₄S
• Molecular Weight: 166.2
• EINECS: 200-258-5
• Mol File: 770-30-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 240-242 °C
• Boiling Point: 379.7ºC at 760 mmHg
• Flash Point: 183.4ºC
• Appearance: Slightly yellow to cream/Powder
• Density: 1.37g/cm3
• Vapor Pressure: 5.75E-06mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.23±0.10(Predicted)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE(770-30-9)
• EPA Substance Registry System: 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE(770-30-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-22
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 770-30-9(Hazardous Substances Data)

Usage

Chemical Properties

slightly yellow to cream powder

Uses

It is used as a pharmaceutical intermediate.

InChI:InChI=1/C6H7N3OS/c1-11-6-8-2-4(3-10)5(7)9-6/h2-3H,1H3,(H2,7,8,9)

Upstream product

• 867-44-7 S-Methylisothiourea sulfate 
• 123-06-8 Ethoxymethylenemalononitrile 
• 4338-95-8 S-methylthiouronium iodide 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 14527-26-5 2-methylisothiourea sulphate 

Downstream Products

• 866002-06-4 4-[(5-cyano-2-methylsulfanyl-pyrimidin-4-ylamino)-methyl]-benzoic acid methyl ester 
• 770-31-0 4-amino-2-(methylthio)pyrimidine-5-carbaldehyde 
• 1229979-94-5 4-amino-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidine-5-carbonitrile 
• 959784-96-4 C₁₄H₁₅N₅O₃ 
• 1415548-29-6 C₂₄H₂₈N₆O₅ 
• 55441-41-3 4-amino-2-(methylthio)pyrimidine-5-carbothioamide 
• 103970-34-9 4-amino-2-methylthiopyrimidine-5-carboxamide O-benzoyl oxime 
• 98198-13-1 4-amino-2-methanesulfonyl-pyrimidine-5-carbonitrile 
• 103151-40-2 4-amino-2-(4-methyl-piperazin-1-yl)-pyrimidine-5-carbonitrile 
• 90973-23-2 4-amino-2-piperidin-1-yl-pyrimidine-5-carbonitrile 
• 99988-17-7 4-amino-2-cyclohexylamino-pyrimidine-5-carbonitrile 
• 78318-43-1 4-Amino-2-morpholino-pyrimidin-5-carbonitril 
• 918662-92-7 N-{5-cyano-2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-pyrimidin-4-yl}-benzamide 
• 918662-91-6 N-[2-(4-benzyl-piperazin-1-yl)-5-cyano-pyrimidin-4-yl]-benzamide 

Relevant articles and documents

Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines

A series of new fist-time synthesized of thiazolyl-substituted 4-aminopyrimidine was obtained on the basis of a two-stage process including thioamidation of 4-amino-5-cyanopyrimide followed by one-pot acylation and Hantzsch synthesis in good yield (52–77%

DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR

Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.