77063-21-9Relevant articles and documents
Efficient Multigram Approach to Acetylenes and CF3-ynones Starting from Dichloroalkenes Prepared by Catalytic Olefination Reaction (COR)
Muzalevskiy, Vasiliy M.,Sizova, Zoia A.,Diusenov, Arstan I.,Shastin, Alexey V.,Nenajdenko, Valentine G.
, p. 4161 - 4166 (2020/07/13)
A novel approach to terminal acetylenes based on catalytic olefination reaction COR of arylaldehydes to form dichloroalkenes followed by treatment with nBuLi was elaborated. This method is atom economical and displays high yields and effectivity. The corresponding alkynes can be prepared in up to 97 % yield. One pot procedure towards CF3-ynones was elaborated to provide these products in up to 87 % yield starting from dichloroalkenes.
Study on the green click-chemistry synthesis of 4-trifluoroacetyl-1,2,3-triazoles
Han, Jie,Ran, Jian-Xiong,Chen, Xiu-Ping,Wang, Zhong-Hua,Wu, Fan-Hong
, p. 6985 - 6992 (2018/10/31)
A metal-free and solvent free click-chemistry procedure has been revealed for the synthesis of 4-trifluoroacetyl-1,2,3-triazoles from corresponding azides and alkyne with high yield and selectivity. The pure products could be easily obtained via crystalli
Bronsted acid catalyzed friedel-crafts alkylation reactions of trifluoromethyl-α,β-ynones with indoles
Sasaki, Shigeru,Ikekame, Yuta,Tanayama, Manabu,Yamauchi, Takayasu,Higashiyama, Kimio
supporting information, p. 2699 - 2703,5 (2012/12/12)
The successful development of a Bronsted acid catalyzed Friedel-Crafts alkylation reaction between trifluoromethyl-α,β-ynones and indoles has been described. The reaction is catalyzed by benzoic acid (5 mol%), with the indoles adding to the carbonyl carbon of the trifluoromethyl-α,β- ynones producing the corresponding 1,2-addition products as trifluoromethyl propargyl alcohols in high yields. Furthermore, treatment of the product with indoles in the presence of trifluoroacetic acid (10 mol%) afforded trifluoromethyl-functionalized unsymmetrical bis(indolyl)propynes in high yields.