77086-22-7 Usage
Uses
Different sources of media describe the Uses of 77086-22-7 differently. You can refer to the following data:
1. (-)-MK-801 MALEATE is probe for NMDA receptors
2. (-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.
3. Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
General Description
A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
Biological Activity
(-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset? .
Biochem/physiol Actions
Primary TargetNMDA receptor
Check Digit Verification of cas no
The CAS Registry Mumber 77086-22-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,8 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 77086-22:
(7*7)+(6*7)+(5*0)+(4*8)+(3*6)+(2*2)+(1*2)=147
147 % 10 = 7
So 77086-22-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1
77086-22-7Relevant articles and documents
Synthesis of dizocilpine
Chang, Meng-Yang,Huang, Yu-Ping,Lee, Tein-Wei,Chen, Yeh-Long
, p. 3283 - 3287 (2012/06/30)
A simple five-step synthetic route toward dizocilpine (1) starting with dibenzosuberenone (2) in 28% of total yield is described. The facile route was carried from by aziridination of dibenzosuberenone (2) with NBS and chloramines-T in MeCN at reflux, hyd
5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof
-
, (2008/06/13)
5-Substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anticonvulsants.
