771-99-3

Basic information

• Product Name: 4-Phenylpiperidine
• Synonyms: RARECHEM AH CK 0160;Piperidine, 4-phenyl-;TIMTEC-BB SBB003943;LABOTEST-BB LT00233204;LABOTEST-BB LTBB000705;AKOS BBS-00003581;4-Phenylpiperidine 97%;4-PHENYLPIPERDINE
• CAS NO: 771-99-3
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.24
• EINECS: 212-243-1
• Product Categories: Amines and Anilines;Piperidines, Piperidones, Piperazines;Piperidine;API intermediates;PYRIDINE;Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 771-99-3.mol
• Article Data: 40

Chemical Properties

• Melting Point: 61-65 °C(lit.)
• Boiling Point: 286 °C(lit.)
• Flash Point: >230 °F
• Appearance: Yellow to brown/Powder
• Density: 1.062 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: n20/D 1.588(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.20±0.10(Predicted)
• Water Solubility: Soluble in water.
• BRN: 124508
• CAS DataBase Reference: 4-Phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenylpiperidine(771-99-3)
• EPA Substance Registry System: 4-Phenylpiperidine(771-99-3)

Safety Data

• Hazard Codes: T,Xi,C,F
• Statements: 36/37/38-34-11-20/21/22
• Safety Statements: 26-36/37/39-45-37/39-36/37-16
• RIDADR: UN 2922 8/PG 2
• WGK Germany: 3
• RTECS: TM2625000
• F: 10
• HazardClass: IRRITANT
• Hazardous Substances Data: 771-99-3(Hazardous Substances Data)

Usage

Chemical Properties

off-white to light brown crystalline powder and/or

Uses

4-Phenylpiperidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Definition

4-Phenylpiperidine is a benzene ring bound to a piperidine ring. It is the base structure for a variety of opioids, such as pethidine (meperidine), ketobemidone, alvimopan, loperamide, and diphenoxylate.

InChI:InChI=1/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2/p+1

Upstream product

• 10338-69-9 1,2,3,6-tetrahydro-4-phenylpyridine 
• 81976-73-0 4-fenil-piperidin-2-one 
• 14149-31-6 4-phenylpiperidine-2,6-dione 
• 62143-51-5 1-(phenylmethyl)-4-phenylpiperidin-2,6-dione 
• 123-91-1 1,4-dioxane 
• 829-27-6 3-phenylpentane-1,5-diol 
• 110-58-7 n-Pentylamine 
• 859981-75-2 3-phenyl-glutaric acid bis-pentylamide 
• 98-83-9 isopropenylbenzene 
• 43064-12-6 1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 19125-34-9 1-phenylpiperidin-4-one 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 71-43-2 benzene 

Downstream Products

• 776-91-0 1-ethyl-4-phenylpiperidine 
• 14813-03-7 4-phenyl-1-propyl-piperidine 
• 774-52-7 1-methyl-4-phenylpiperidine 
• 16376-62-8 3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 34588-04-0 3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazole-2-thione 
• 23002-85-9 3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzothiazole-2-thione 
• 16376-63-9 5-chloro-3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 56953-33-4 N-(β-idrossietil)-4-fenilpiperidina 
• 120447-50-9 (+/-)-N-(2-hydroxybutyl)-4-phenylpiperidine hydrochloride 
• 70175-20-1 2,2'-bis-(4-phenyl-piperidin-1-yl)-N,N'-benzo[1,2-d;5,4-d']bisthiazole-2,6-diyl-bis-acetamide 
• 136534-52-6 4-Phenyl-1-(3-phenyl-propyl)-piperidine 
• 104837-20-9 6-Benzoyl-3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 116437-26-4 1-<(tert-butyldioxy)methyl>-4-phenylpiperidine 
• 114518-32-0 1-[5-(4-Fluoro-phenyl)-1H-pyrrol-2-ylmethyl]-4-phenyl-piperidine 

Relevant articles and documents

Synthetic method of 4 -phenyl piperidine hydrochloride

The invention discloses a synthesis method of 4 -phenylpiperidine hydrochloride, and the route is as shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation and post-treatment, high yield, high product purity and the like, and is suitable for industrial production.

Cobalt-bridged secondary building units in a titanium metal-organic framework catalyze cascade reduction of N-heteroarenes

We report here a novel Ti3-BPDC metal-organic framework (MOF) constructed from biphenyl-4,4′-dicarboxylate (BPDC) linkers and Ti3(OH)2 secondary building units (SBUs) with permanent porosity and large 1D channels. Ti-OH groups from neighboring SBUs point toward each other with an O-O distance of 2 ?, and upon deprotonation, act as the first bidentate SBU-based ligands to support CoII-hydride species for effective cascade reduction of N-heteroarenes (such as pyridines and quinolines) via sequential dearomative hydroboration and hydrogenation, affording piperidine and 1,2,3,4-tetrahydroquinoline derivatives with excellent activity (turnover number ～ 1980) and chemoselectivity.

Hydrogenation of Pyridines Using a Nitrogen-Modified Titania-Supported Cobalt Catalyst

Novel heterogeneous catalysts were prepared by impregnation of titania with a solution of cobalt acetate/melamine and subsequent pyrolysis. The resulting materials show an unusual nitrogen-modified titanium structure through partial implementation of nitrogen into the support. The optimal catalyst displayed good activity and selectivity for challenging pyridine hydrogenation under acid free conditions in water as solvent.