771580-80-4

Basic information

• Product Name: 2-chloro-3,4-dimethoxy-benzylamine
• Synonyms: 2-chloro-3,4-dimethoxy-benzylamine
• CAS NO: 771580-80-4
• Molecular Weight: 201.653
• Mol File: 771580-80-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-3,4-dimethoxy-benzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3,4-dimethoxy-benzylamine(771580-80-4)
• EPA Substance Registry System: 2-chloro-3,4-dimethoxy-benzylamine(771580-80-4)

Safety Data

• Hazardous Substances Data: 771580-80-4(Hazardous Substances Data)

Upstream product

• 175136-02-4 C₉H₁₀ClNO₃ 
• 857521-63-2 2-chloro-3,4-dimethoxy-benzaldehyde oxime 

Relevant articles and documents

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. Exploration of the structure-activity relationships within this series yielded compound 13, which displayed an ERCC1-XPF IC50 of 0.6 μM, high selectivity against FEN-1 and DNase I and activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays in A375 melanoma cells. Screening of fragments as potential alternatives to the catechol group revealed that 3-hydroxypyridones are able to inhibit ERCC1-XPF with high ligand efficiency, and elaboration of the hit gave compounds 36 and 37 which showed promising ERCC1-XPF IC50 values of 10 μM.