77262-41-0

Basic information

• Product Name: N-(2,2,2-trifluoroethyl)pyridin-2-amine
• Synonyms: N-(2,2,2-trifluoroethyl)pyridin-2-amine
• CAS NO: 77262-41-0
• Molecular Formula: C₇H₇F₃N₂
• Molecular Weight: 176.14
• Mol File: 77262-41-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 200.123°C at 760 mmHg
• Flash Point: 74.832°C
• Appearance: /
• Density: 1.305g/cm³
• Vapor Pressure: 0.33mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: N-(2,2,2-trifluoroethyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2,2-trifluoroethyl)pyridin-2-amine(77262-41-0)
• EPA Substance Registry System: N-(2,2,2-trifluoroethyl)pyridin-2-amine(77262-41-0)

Safety Data

• Hazardous Substances Data: 77262-41-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7F3N2/c8-7(9,10)5-12-6-3-1-2-4-11-6/h1-4H,5H2,(H,11,12)

Upstream product

• 504-29-0 2-aminopyridine 
• 109-04-6 2-bromo-pyridine 
• 753-90-2 trifluoroethylamine 
• 109-09-1 2-chloropyridine 
• 372-48-5 2-fluoropyridine 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 457-50-1 2,2,2-trifluoro-n-pyridin-2-yl-acetamide 

Downstream Products

• 1176948-72-3 2-hydroxy-4-oxo-3-phenyl-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium inner salt 
• 1263050-37-8 3-[3-(cyanomethoxy)phenyl]-2-oxido-4-oxo-1-(2,2,2-trifluoroethyl)-4H-pyrido[1,2-a]pyrimidinium 

Relevant articles and documents

Synthesis of tri(di)fluoroethylanilines via copper-catalyzed coupling reaction of tri(di)fluoroethylamine with (hetero)aromatic bromides

We have realized the first Ullmann type coupling reaction of tri(di)fluoroethylamine with (hetero)aromatic bromides, employing 5-20 mol% Cu2O and an oxalamide ligand [N-(2,4,6-trimethoxyphenyl)acetamide]. This efficient and practical method has

AROMATIC COMPOUND

Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.

Palladium-Catalyzed Arylation of Fluoroalkylamines

We report the synthesis of fluorinated anilines by palladium-catalyzed coupling of fluoroalkylamines with aryl bromides and aryl chlorides. The products of these reactions are valuable because anilines typically require the presence of an electron-withdrawing substituent on nitrogen to suppress aerobic or metabolic oxidation, and the fluoroalkyl groups have steric properties and polarity distinct from those of more common electron-withdrawing amide and sulfonamide units. The fluoroalkylaniline products are unstable under typical conditions for C-N coupling reactions (heat and strong base). However, the reactions conducted with the weaker base KOPh, which has rarely been used in cross-coupling to form C-N bonds, occurred in high yield in the presence of a catalyst derived from commercially available AdBippyPhos and [Pd(allyl)Cl]2. Under these conditions, the reactions occur with low catalyst loadings (0.50 mol % for most substrates) and tolerate the presence of various functional groups that react with the strong bases that are typically used in Pd-catalyzed C-N cross-coupling reactions of aryl halides. The resting state of the catalyst is the phenoxide complex, (BippyPhosPd(Ar)OPh); due to the electron-withdrawing property of the fluoroalkyl substituent, the turnover-limiting step of the reaction is reductive elimination to form the C-N bond.