77287-58-2

Basic information

• Product Name: 2-Iodo-5-methoxybenzaldehyde
• Synonyms: 2-Iodo-5-methoxybenzaldehyde;2-Iodo-5-methoxybenzaldehyd
• CAS NO: 77287-58-2
• Molecular Formula: C₈H₇IO₂
• Molecular Weight: 262.04445
• Product Categories: Building Blocks;C2 to C8;Chemical Synthesis;Ethers;New Products for Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;aldehyde| alkyl Iodine
• Mol File: 77287-58-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 110-115℃
• Appearance: White to off-white to yellow/Solid
• Sensitive: Air & Light Sensitive
• CAS DataBase Reference: 2-Iodo-5-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-5-methoxybenzaldehyde(77287-58-2)
• EPA Substance Registry System: 2-Iodo-5-methoxybenzaldehyde(77287-58-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• Hazardous Substances Data: 77287-58-2(Hazardous Substances Data)

Usage

General Description

2-Iodo-5-methoxybenzaldehyde, also known as 5-Methoxy-2-iodobenzaldehyde, is a chemical compound with the molecular formula C8H7IO2. It is a white to light yellow crystalline powder that is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The presence of the iodo and methoxy groups on the benzene ring make this compound suitable for use in various organic transformations, including nucleophilic substitution and aromatic coupling reactions. It is also known for its potential as a starting material for the synthesis of biologically active compounds and as a building block for the development of new drugs. However, it is important to handle this compound carefully as it is potentially harmful if inhaled or ingested and can cause irritation to the skin and eyes.

Upstream product

• 150192-39-5 2-Bromo-5-methoxybenzyl alcohol 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 591-31-1 3-methoxy-benzaldehyde 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 54413-93-3 2-iodo-5-methoxybenzoic acid 
• 6971-51-3 3-methoxybenzyl alcohol 
• 139557-96-3 (2-iodo-5-methoxyphenyl)methanol 

Downstream Products

• 1416476-21-5 C₁₀H₁₁IO 
• 1416476-25-9 C₁₀H₁₁IO 
• 99254-50-9 β-(2-iodo-5-methoxyphenyl)propionic acid 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 132901-31-6 4,4′-dimethoxy[1,1′-biphenyl]-2,2′-dicarbaldehyde 
• 118545-81-6 4,4'-bis-(2H-chromen-2-one) 
• 265308-37-0 4-[(Z)-1-Ethoxycarbonyl-2-(2-iodo-5-methoxy-phenyl)-vinylamino]-benzoic acid ethyl ester 

Relevant articles and documents

INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE - SYNTHESIS AND USE THEREOF FOR TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOMA

The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.

Regioselectivity Influences in Platinum-Catalyzed Intramolecular Alkyne O-H and N-H Additions

The steric and electronic drivers of regioselectivity in platinum-catalyzed intramolecular hydroalkoxylation are elucidated. A branch point is found that divides the process between 5-exo and 6-endo selective processes, and enol ethers can be accessed in good yields for both oxygen heterocycles. The main influence arises from an electronic effect, where the alkyne substituent induces a polarization of the alkyne that leads to preferential heteroatom attack at the more electron-deficient carbon. The electronic effects are studied in other contexts, including hydroacyloxylation and hydroamination, and similar trends in directionality are predominant although not uniformly observed.

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.