77290-30-3

Basic information

• Product Name: TERT-BUTYL 4-(4-CHLOROBENZYL)PIPERAZINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 4-(4-CHLOROBENZYL)PIPERAZINE-1-CARBOXYLATE
• CAS NO: 77290-30-3
• Molecular Formula: C₁₆H₂₃ClN₂O₂
• Molecular Weight: 310.82
• Mol File: 77290-30-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 388.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• PKA: 6.11±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-(4-CHLOROBENZYL)PIPERAZINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(4-CHLOROBENZYL)PIPERAZINE-1-CARBOXYLATE(77290-30-3)
• EPA Substance Registry System: TERT-BUTYL 4-(4-CHLOROBENZYL)PIPERAZINE-1-CARBOXYLATE(77290-30-3)

Safety Data

• Hazardous Substances Data: 77290-30-3(Hazardous Substances Data)

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1326756-44-8 (4-(4-chlorobenzyl)piperazin-1-yl)(morpholino)methanone 
• 1374602-24-0 C₂₉H₃₈Cl₂N₄O₂ 
• 218911-25-2 1-[4-(4-chlorobenzyl)piperazin-1-yl]-3-phenylpropan-2-one 
• 23145-88-2 1-[(4-chlorophenyl)methyl]piperazine 

Relevant articles and documents

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)

Inhibitors of the aldo-keto reductase enzyme AKR1C3 are of interest as potential drugs for leukemia and hormone-related cancers A series of non-carboxylate morpholino(phenylpiperazin-1-yl)methanones were prepared by palladium-catalysed coupling of substit

Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor

Two novel series of 3-(heterocyclylmethyl)pyrazoles have been synthesised and evaluated as ligands for the human dopamine D4 receptor. Compounds in series I (exemplified by 8k) have a phenyl ring joined to the 4-position of the pyrazole while those in series II (exemplified by 15j) have a 5-phenyl ring linked by a saturated chain to the 4-position of the pyrazole. Both series supplied compounds with excellent affinity for the human D4 and good selectivity over other dopamine receptors. Excellent selectivity over calcium, sodium, and potassium ion channels was also achieved. Copyright (C) 1997 Elsevier Science Ltd.