77335-93-4

Basic information

• Product Name: 5-METHYL-2-PHENYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-METHYL-2-PHENYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid ethyl ester;4-methyl-2-phenyl-1h-imidazole-5-carboxylic acid Ethyl ester
• CAS NO: 77335-93-4
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.26
• Mol File: 77335-93-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-2-PHENYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-PHENYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(77335-93-4)
• EPA Substance Registry System: 5-METHYL-2-PHENYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(77335-93-4)

Safety Data

• Hazardous Substances Data: 77335-93-4(Hazardous Substances Data)

Upstream product

• 14369-88-1 (±)-ethyl 3-methyl-2H-azirine-2-carboxylate 
• 825-60-5 benzimidic acid ethyl ester 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 623-49-4 ethyl cyanoformate 
• 2198-64-3 N-Benzoylalanine 
• 98-88-4 benzoyl chloride 
• 100-46-9 benzylamine 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 20207-16-3 ethyl 2-amino-3-oxobutanoate hydrochloride 
• 7471-86-5 methyl benzimidate 
• 100-52-7 benzaldehyde 
• 1723-25-7 ethyl 2,3-dioxobutyrate 

Downstream Products

• 1404493-67-9 C₁₉H₁₆N₂OS₂ 
• 1404493-68-0 C₁₉H₁₅ClN₂OS₂ 
• 1404493-69-1 C₁₉H₁₄ClFN₂OS₂ 
• 1404493-70-4 C₁₉H₁₅FN₂OS₂ 
• 68282-50-8 5-Methyl-2-phenyl-3H-imidazole-4-carbaldehyde 
• 13682-32-1 4-Hydroxymethyl-5-methyl-2-phenyl-3H-imidazole 
• 1404493-71-5 C₂₀H₁₈N₂O₂S₂ 
• 1404493-72-6 C₂₀H₁₈N₂OS₂ 
• 827-43-0 4-methyl-2-phenyl-1H-imidazole 
• 28824-94-4 5-methyl-2-phenyl-1⁽³⁾H-imidazole-4-carboxylic acid 
• 97878-92-7 N-acetyl-4,5-dimethyl-2-phenylimidazole 
• 13682-20-7 4,5-dimethyl-2-phenyl-1H-imidazole 

Relevant articles and documents

ZnCl2-Catalyzed [3 + 2] Cycloaddition of Benzimidates and 2 H-Azirines for the Synthesis of Imidazoles

ZnCl2-catalyzed [3 + 2] cycloaddition reaction of benzimidates and 2H-azirines has been developed. This convenient method allowed the efficient construction of a series of multisubstituted imidazoles in moderate to good yields under mild reaction conditions. This transformation exhibits good reactivity and high functional group tolerance.

AROMATIC HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY

A compound having TRPV4 inhibitory activity or a pharmaceutically acceptable salt thereof is provided. The present invention is related to a compound represented by the formula (I). wherein R1a is substituted or unsubstituted alkyl or the like;

Syntheses of 2-Arylimidazole Derivatives through Annelations Employing Benzylamines

Annelations of benzylamines with hydroximino derivatives of pentane-2,4-dione or of alkyl acetoacetates, acetoacetamides, and acetoacetanilides, afford imidazole derivatives and provide easy incorporation of the benzylic carbon and nitrogen in the heterocycle.The limits of the reaction have been explored.