77337-73-6 Usage
Description
Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; ). Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 μM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release. It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors. Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.
Chemical Properties
Acamprosate calcium is White Crystalline Solid
Uses
Different sources of media describe the Uses of 77337-73-6 differently. You can refer to the following data:
1. Of interest for the treatment of alcoholism. Store at -20°C
2. Of interest for the treatment of alcoholism and other neurochemical disorders.
3. Acamprosate calcium is a synthetic amino acid and a neurotransmitter analogue that is used as an alcohol deterrent in management of alcohol dependence and abuse. Acamprosate calcium was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004.
Biological Activity
GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
Biochem/physiol Actions
Acamprosate calcium is a GABA γ-aminobutyric acid agonist.
Clinical Use
Maintenance of abstinence in alcohol dependence
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
Acamprosate is excreted in the urine and is not
metabolised significantly.
references
1. wilde m i, wagstaff a j. acamprosate. drugs, 1997, 53(6): 1038-1053.
Check Digit Verification of cas no
The CAS Registry Mumber 77337-73-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,3,3 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 77337-73:
(7*7)+(6*7)+(5*3)+(4*3)+(3*7)+(2*7)+(1*3)=156
156 % 10 = 6
So 77337-73-6 is a valid CAS Registry Number.
InChI:InChI=1/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2
