7734-80-7

Basic information

• Product Name: Coumarin-6-carboxylic acid
• Synonyms: Coumarin-6-carboxylic acid;2-oxo-2H-1-Benzopyran-6-carboxylic acid
• CAS NO: 7734-80-7
• Molecular Formula: C₁₀H₆O₄
• Molecular Weight: 190.15224
• EINECS: 1312995-182-4
• Mol File: 7734-80-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 270-271 °C
• Boiling Point: 440oC at 760 mmHg
• Flash Point: 185.4oC
• Appearance: /
• Density: 1.466g/cm3
• Vapor Pressure: 1.61E-08mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.83±0.20(Predicted)
• CAS DataBase Reference: Coumarin-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Coumarin-6-carboxylic acid(7734-80-7)
• EPA Substance Registry System: Coumarin-6-carboxylic acid(7734-80-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7734-80-7(Hazardous Substances Data)

Usage

General Description

Coumarin-6-carboxylic acid is a chemical compound that belongs to the coumarin family, known for their unique fragrant properties and their role as an important synthetic intermediate in the pharmaceutical industry. This pale tan or off-white crystalline chemical exhibits good fluorescence and is used in biological and biochemical research as a specific stain and tracer. Its properties make it essential in analyzing particle translocation behaviors in cells (cytochemistry), as well as drug delivery mechanisms. As promising as it seems, however, concerns have been raised about its potential health hazards as it might impair liver function after long-term exposure.

InChI:InChI=1/C10H6O4/c11-9-4-2-6-5-7(10(12)13)1-3-8(6)14-9/h1-5H,(H,12,13)

Upstream product

• 51690-26-7 coumarin-6-carboxaldehyde 
• 1310535-74-0 6-vinyl-2H-chromen-2-one 
• 92-48-8 6-methylcoumarin 
• 617-48-1 malic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 50396-61-7 2-oxo-2H-chromene-6-carbonitrile 

Downstream Products

• 947408-90-4 6-(2,4-dimethoxybenzoyl)chromen-2-one 
• 874204-71-4 methyl 3-[2-isobutoxy-5-(4-isobutoxybenzoyl)phenyl]propionate 
• 874204-75-8 methyl 3-[2-hydroxy-5-(4-isobutoxybenzoyl)phenyl]propionate 
• 269082-09-9 3-(2-isobutoxy-5-(4-isobutoxybenzoyl)phenyl)propionic acid 
• 947409-01-0 methyl 3-[2-[(2-trityl-3-keto-benzisoxazol-6-yl)methoxy]-5-(2-hydroxy-4-cyclopentyloxybenzoyl)phenyl]propionate 
• 530141-60-7 methyl 3-[2-hydroxy-5-(2-hydroxy-4-cyclopentyloxybenzoyl)phenyl]propionate 
• 947408-93-7 6-(2-hydroxy-4-cyclopentyloxybenzoyl)coumarin 
• 947408-91-5 6-(2,4-dihydroxybenzoyl)chromen-2-one 

Relevant articles and documents

A 4,4 '-di-substituted diphenyl ketone compound and its preparation method

The invention provides a 4,4'-dibasic benzophenone compound which has a structure shown in the following formula I. The compound can well inhibit activities of an AP-1 protein and an NDM-1 protein and has the IC50 value of 52.93 plus and minus 11.86muM fo

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BEZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS

A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an opti