774225-25-1

Basic information

• Product Name: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine
• Synonyms: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine
• CAS NO: 774225-25-1
• Molecular Weight: 381.88
• Mol File: 774225-25-1.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine(774225-25-1)
• EPA Substance Registry System: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine(774225-25-1)

Safety Data

• Hazardous Substances Data: 774225-25-1(Hazardous Substances Data)

Upstream product

• 532-32-1 sodium benzoate 
• 4248-19-5 tert-butyl carbazate 
• 104-88-1 4-chlorobenzaldehyde 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 1273585-66-2 methyl 2-(tert-butoxycarbonylamino)-2-(4-chlorophenyl)acetate 
• 120157-95-1 (4-chlorobenzyl)carbamic acid tert-butyl ester 
• 53994-85-7 (±)-2-(tert-butoxycarbonyl)-2-(4-chlorophenyl)acetic Acid 
• 1415303-93-3 C₂₀H₂₆ClNO₂Si 
• 104-88-1 4-chlorobenzaldehyde 
• 779342-75-5 tert-butyl 4-chlorobenzylidenecarbamate 
• 1429382-50-2 (±)-tert-butyl 2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-oxoethylcarbamate 

Relevant articles and documents

Enantioselective Construction of Sulfur-Containing Tetrasubstituted Stereocenters via Asymmetric Functionalizations of α-Sulfanyl Cyclic Ketones

Asymmetric functionalizations of α-sulfanyl cyclic ketones were realized via chiral phosphoric acid catalyzed enantioselective addition reactions with aldimines, azodicarboxylates and allenamides. A series of chiral organosulfur compounds possessing sulfur-containing tetrasubstituted stereocenters were accessed via these methods, with excellent regioselectivities and high stereoselectivities. (Figure presented.).

Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers

A practical method for the synthesis of phenyl enol ethers is reported. The combination of a gold(I) catalyst and potassium carbonate selectively mediates the addition of phenols to propargylic alcohols/amines in a chemo-, regio-, and stereoselective fash

Direct Catalytic Asymmetric Mannich-Type Reaction en Route to α-Hydroxy-β-amino Acid Derivatives

A direct catalytic Mannich-type reaction of α-oxygen-functionalized amides was achieved. The use of 7-azaindoline amide was crucial to facilitate direct enolization and subsequent stereoselective addition to imines in a cooperative catalytic system comprising a soft Lewis acid and Br?nsted base. The operationally simple room-temperature protocol furnished a syn-Mannich adduct with high stereoselectivity. Divergent functional group transformation of the amide moiety of the product allowed for expeditious access to enantioenriched syn-configured α-hydroxy-β-amino carboxylic acid derivatives, highlighting the synthetic utility of the present catalysis.