7745-92-8

Basic information

• Product Name: 2-Iodo-4-nitrotoluene
• Synonyms: AKOS BBS-00002965;2-IODO-4-NITROTOLUENE;TIMTEC-BB SBB005821;2-IODO-1-METHYL-4-NITROBENZENE;1-Methyl-2-iodo-4-nitrobenzene;1-Nitro-3-iodo-4-methylbenzene;2-Methyl-5-nitro-1-iodobenzene;2-Iodo-4-nitrotoluene,98%
• CAS NO: 7745-92-8
• Molecular Formula: C₇H₆INO₂
• Molecular Weight: 263.03
• EINECS: 231-808-3
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;API intermediates;Iodine Compounds;Nitro Compounds
• Mol File: 7745-92-8.mol
• Article Data: 21

Chemical Properties

• Melting Point: 60-62°C
• Boiling Point: 165 °C / 15mmHg
• Flash Point: 141 °C
• Appearance: white to light yellow crystal powder
• Density: 1.883 g/cm³
• Storage Temp.: Refrigerated.
• Solubility: Soluble in toluene.
• Sensitive: Light Sensitive
• Stability: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, strong acids.
• CAS DataBase Reference: 2-Iodo-4-nitrotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-4-nitrotoluene(7745-92-8)
• EPA Substance Registry System: 2-Iodo-4-nitrotoluene(7745-92-8)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 7745-92-8(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

2-Iodo-4-nitrotoluene is used as a pharmaceutical intermediate, chemical synthesis intermediate.

InChI:InChI=1/C7H6INO2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,1H3

Upstream product

• 7745-93-9 2-bromo-4-nitrotoluene 
• 615-37-2 ortho-methylphenyl iodide 
• 99-55-8 2-methyl-5-nitroaniline 
• 99-99-0 1-methyl-4-nitrobenzene 

Downstream Products

• 89459-38-1 4-nitro-2-iodobenzoic acid 
• 318968-55-7 2-dichloroiodanyl-4-nitro-toluene; hydrochloride 
• 89642-21-7 1-bromomethyl-2-iodo-4-nitrobenzene 
• 116631-87-9 4-hydroxy-2-iodo-benzoic acid 
• 35944-64-0 3-iodo-4-methylaniline 
• 101257-14-1 6-Jod-3,4-dinitro-toluol 
• 29270-49-3 2-iodo-4,6-dinitrotoluene 
• 1250296-92-4 1-methyl-2-phenoxy-4-nitro-benzene 
• 99-55-8 2-methyl-5-nitroaniline 
• 939-83-3 2-cyano-4-nitrotoluene 
• 596821-87-3 N-Ethyl-2-iodo-4-nitro-N-phenyl-benzamide 
• 711010-26-3 9-amino-5-ethyl-5H-phenanthridin-6-one 
• 711010-35-4 5-Ethyl-5,6-dihydro-phenanthridin-9-ylamine 

Relevant articles and documents

Rapid and efficient copper-catalyzed finkelstein reaction of (hetero)aromatics under continuous-flow conditions

A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad spectrum of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide solutions were used in two distinct multistep continuous-flow processes (amidation and Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of this method.

IBX-I2 redox couple for facile generation of IOH and I +: Expedient protocol for iodohydroxylation of olefins and iodination of aromatics

(Chemical Equation Presented) IBX is readily reduced to IBAin the presence of molecular iodine in DMSO to generate hypoiodous acid (IOH), which reacts with a variety of olefins as well as R, β-unsaturated ketones leading to their respective iodohydrins with anti stereochemistry. The same redox chemistry in acetonitrile containing TFA produces iodonium ions for facile iodination of a variety of aromatic compounds in respectable isolated yields.

Facile iodination of aromatic compounds having electron-withdrawing substituents. Generation of triiodine cation in the system tetra-N- iodoglycoluril-iodine-sulfuric acid

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