77450-00-1

Basic information

• Product Name: (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester
• Synonyms: (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester
• CAS NO: 77450-00-1
• Molecular Weight: 259.302
• Mol File: 77450-00-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 350.2±42.0 °C(Predicted)
• Density: 1.189±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester(77450-00-1)
• EPA Substance Registry System: (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester(77450-00-1)

Safety Data

• Hazardous Substances Data: 77450-00-1(Hazardous Substances Data)

Usage

General Description

(2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester is a chemical compound that is derived from the amino acid proline. It is a derivative of proline, which is essential for the synthesis of collagen and other proteins. (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester is a tert-butyl and ethyl ester derivative of 4-hydroxyproline-1,2-dicarboxylic acid. It is commonly used in the field of organic chemistry as a chiral building block for the synthesis of complex molecules and pharmaceuticals. (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester is important in drug discovery and development, as it is used to create new potential therapeutic agents with improved pharmacological properties. Additionally, its unique structure and properties make it valuable for studying the structure-activity relationships of different molecules.

Downstream Products

• 404346-77-6 (1R,2R,6R,7aR)-1,2,6-trihydroxyhexahydro-1H-pyrrolizine-1,2,6-triol 
• 1338549-50-0 (2R,4S)-2-(N₃-benzoylthymine-1-ylmethyl)-4-carboxymethoxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 1338549-38-4 (2R,4S)-2-(N₃-benzoylthymine-1-ylmethyl)-4-tert-butoxycarbonylmethyoxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 1338549-34-0 (2R,4S)-4-tert-butoxycarbonylmethoxy-2-(4-tosyloxymethyl)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 1346163-26-5 (1S,6R,7aR,E)-2-(4-hydroxybenzylidene)hexahydro-1H-pyrrolizine-1,6-diol 
• 1346163-25-4 (1S,6R,7aR,Z)-2-benzylidenehexahydro-1H-pyrrolizine-1,6-diol 
• 1346163-24-3 (1S,2R,6R,7aR)-2-(4-hydroxybenzyl)hexahydro-1H-pyrrolizine-1,6-diol 
• 1346163-23-2 (1S,2S,6R,7aR)-1,6-dihydroxy-2-(4-hydroxybenzyl)tetrahydro-1H-pyrrolizin-3(2H)-one 
• 1346163-22-1 (1S,2R,6R,7aR)-2-benzylhexahydro-1H-pyrrolizine-1,6-diol 
• 1346163-21-0 (1S,2S,6R,7aR)-2-benzyl-1,6-dihydroxytetrahydro-1H-pyrrolizin-3(2H)-one 
• 1346163-20-9 (1S,6R,7aR,,Z)-1,6-dihydroxy-2-(4-nitrobenzylidene)tetrahydro-1H-pyrrolizin-3(2H)-one 

Relevant articles and documents

A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines

A concise synthesis of (2R,4R)-4-hydroxyproline (1) and (2S,4S)-4-hydroxyproline (2) has been developed in enantiomerically pure form from commercially available starting materials with excellent diastereoselectivity. The tightly bound chelation controlled transition state formed during the 5-exo-tet ring closure reaction is assumed to be the origin of high diastereoselectivity.