77474-99-8

Basic information

• Product Name: tert-butyl 1H-benzo[d]iMidazol-2-ylcarbaMate
• Synonyms: tert-butyl 1H-benzo[d]iMidazol-2-ylcarbaMate
• CAS NO: 77474-99-8
• Molecular Formula: C₁₂H₁₅N₃O₂
• Molecular Weight: 233.2664
• Mol File: 77474-99-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 196-197 °C
• Appearance: /
• Density: 1.267±0.06 g/cm3(Predicted)
• PKA: 11.13±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 1H-benzo[d]iMidazol-2-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1H-benzo[d]iMidazol-2-ylcarbaMate(77474-99-8)
• EPA Substance Registry System: tert-butyl 1H-benzo[d]iMidazol-2-ylcarbaMate(77474-99-8)

Safety Data

• Hazardous Substances Data: 77474-99-8(Hazardous Substances Data)

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 29427-57-4 t-butylcarboxy imidoyl dichloride 
• 95-54-5 1,2-diamino-benzene 
• 302912-11-4 2-benzyl-1,3-bis(tert-butoxycarbonyl)-isothiourea 

Relevant articles and documents

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly.

Benzo five-membered heterocyclic IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor, preparation method thereof and application

The invention belongs to the field of medicines, and particularly relates to a benzo five-membered heterocyclic compound or pharmaceutically acceptable salt of the compound, a preparation method of the compound and an application of the compound serving as an IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor. Experimental results indicate that the compound has a remarkable inhibiting effect on activity of IDO1, T cell proliferation can be effectively promoted, differentiation of initial T cells into regulatory T cells is inhibited, IDO1-mediated immune inhibition is reversed, and the compound can be used for treating related diseases with pathological features of an IDO1-mediated kynurenine metabolic pathway, wherein the related diseases include cancer, virus infection, neurodegenerative diseases, cataract, organ transplant rejection, depression and autoimmune diseases.