77557-01-8

Basic information

• Product Name: 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI)
• Synonyms: 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI);1-Propyl-3H-1,3-benzodiazol-2-one;3-propyl-1H-benzimidazol-2-one
• CAS NO: 77557-01-8
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.21508
• Product Categories: BENZIMIDAZOLE
• Mol File: 77557-01-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.128 g/cm³
• Refractive Index: 1.556
• CAS DataBase Reference: 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI)(77557-01-8)
• EPA Substance Registry System: 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI)(77557-01-8)

Safety Data

• Hazardous Substances Data: 77557-01-8(Hazardous Substances Data)

Usage

Description

2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI), also known as 1,3-Dihydro-1-propyl-2H-benzimidazol-2-one, is a chemical compound belonging to the benzimidazole class. It has the molecular formula C12H14N2O and is characterized by its white crystalline powder form. 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI) is utilized in the synthesis of pharmaceuticals and other organic compounds, and it possesses potential biological activities. Its unique structure and properties make it a valuable building block in medicinal chemistry research and a promising candidate for the development of new drugs and therapeutic agents.

Uses

Used in Pharmaceutical Synthesis:
2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the design and development of new drugs, enhancing their therapeutic properties and effectiveness.
Used in Medicinal Chemistry Research:
As a building block in medicinal chemistry, 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI) is employed for the exploration of its potential biological activities. Researchers use this compound to investigate its interactions with biological targets and its potential role in the treatment of various diseases.
Used in Drug Development:
Due to its unique structure and properties, 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI) has potential applications in the development of new drugs and therapeutic agents. Its versatility in chemical synthesis and potential biological activities make it a valuable asset in the creation of innovative treatments for various medical conditions.
Used in Organic Compound Synthesis:
Beyond its pharmaceutical applications, 2H-Benzimidazol-2-one,1,3-dihydro-1-propyl-(9CI) is also utilized in the synthesis of other organic compounds. Its reactivity and structural features contribute to the development of new organic molecules with diverse applications in various industries.

InChI:InChI=1/C10H12N2O/c1-2-7-12-9-6-4-3-5-8(9)11-10(12)13/h3-6H,2,7H2,1H3,(H,11,13)

Upstream product

• 622-80-0 N-propylaniline 
• 55240-30-7 N-n-propyl-N-phenyl carbamoyl chloride 
• 16062-69-4 2-propyl-4H-benzo[d][1,3]oxazin-4-one 

Downstream Products

• 929565-12-8 1-[(1S)-3-(chloro)-1-phenylpropyl]-3-propyl-1,3-dihydro-2H-benzimidazol-2-one 
• 1057215-52-7 1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one 
• 929565-15-1 1-[(1R)-3-(chloro)-1-phenylpropyl]-3-propyl-1,3-dihydro-2H-benzimidazol-2-one 

Relevant articles and documents

Photocatalytic Intramolecular C-H Amination Using N-Oxyureas as Nitrene Precursors

Nitrenes are remarkable high-energy chemical species that enable direct C-N bond formation, typically via controlled reactions of metal-stabilized nitrenes. Here, in contrast, the combined use of photocatalysis with careful engineering of the precursor enabled C-H amination forming imidazolidinones and related nitrogen heterocycles from readily accessible hydroxylamine precursors. Preliminary mechanistic results are consistent with the formation of free carbamoyl triplet nitrenes as reactive intermediates.