7766-86-1

Basic information

• Product Name: 5-Oxo-2-pyrrolidinepropanoic acid
• Synonyms: 5-Oxo-2-pyrrolidinepropanoic acid;PD-106687;3-(5-Oxopyrrolidin-2-yl)propanoic acid
• CAS NO: 7766-86-1
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.17
• Mol File: 7766-86-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 126-127 °C(Solv: ethanol (64-17-5); benzene (71-43-2))
• Boiling Point: 435.1±18.0 °C(Predicted)
• Appearance: /
• Density: 1.209±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.59±0.10(Predicted)
• CAS DataBase Reference: 5-Oxo-2-pyrrolidinepropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Oxo-2-pyrrolidinepropanoic acid(7766-86-1)
• EPA Substance Registry System: 5-Oxo-2-pyrrolidinepropanoic acid(7766-86-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7766-86-1(Hazardous Substances Data)

Usage

Uses

5-Oxo-2-pyrrolidinepropanoic Acid, can be used for the synthesis of a series of Dihydro-lH-pyrrolizine-3,5(2H,6H)-dion, having the ability to reverse electroconvulsive shock (ECS) induced amnesia in mice.

Upstream product

• 18356-28-0 tetrahydro-pyrrolizin-3,5-dione 
• 7440-44-0 pyrographite 
• 77287-34-4 formamide 
• 7766-85-0 4-aminopimelic acid 

Downstream Products

• 431988-79-3 5-(3-oxo-4-phenyl-butyl)-pyrrolidin-2-one 
• 643-20-9 pyrrolizidine 
• 89317-06-6 5-oxo-2-pyrrolidinepropanoic acid benzyl ester 
• 18356-28-0 tetrahydro-pyrrolizin-3,5-dione 

Relevant articles and documents

Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione

Dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione is produced in higher overall yield in a process which comprises catalytically hydrogenating a lower alkyl ester of 4-(hydroxyimino)heptanedioic acid in the presence of a tri-(lower alkyl)amine, followed by cyclization of the product thus produced in the presence of a cyclizing agent such as acetic anhydride.

(E)-5-Hydroxypyrrolizidin-3-one: Versatile Synthon for the Synthesis of 5-Substituted 2-Pyrrolidones and (Z)-3-Alkylpyrrolizidines

Carbinol lactam 6 of secured stereochemistry served as a synthon to prepare 5-substituted 2-pyrrolidones and pyrrolizidin-3-ones.The relative stereochemistry of 6 and the dithioketal 13, prepared from the keto lactam 11, was established by single-crystal X-ray analysis.Desulfurization of the dithioketals 13 and 14 afforded the 5-n-propylpyrrolizidin-3-ones 15 and 16.Reduction of lactam 15 with LiAlH4 gave the racemic (Z)-3-n-propylpyrrolizidine (17), an analogue of a substance recently detected in ant species.