77770-09-3

Basic information

• Product Name: 5-IODO-2-METHOXYANILINE
• Synonyms: 5-IODO-2-METHOXYANILINE;5-IODO-O-ANISIDINE;5-Iodo-2-methoxyaniline,97%;2-amino-4-iodoanisole;BenzenaMine, 5-iodo-2-Methoxy-;2-Amino-4-iodoanisole, 5-Iodo-o-anisidine;2-AMino-4-iodoanisole[5-Iodo-2-Methoxyaniline];4-Methoxy-3-amino-1-iodobenzene
• CAS NO: 77770-09-3
• Molecular Formula: C₇H₈INO
• Molecular Weight: 249.05
• Mol File: 77770-09-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 85-87°C
• Boiling Point: 304.3 °C at 760 mmHg
• Flash Point: 137.8 °C
• Appearance: /
• Density: 1.807 g/cm³
• Vapor Pressure: 0.000884mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.58±0.10(Predicted)
• Water Solubility: Sparingly soluble in water 0.87 g/L @ 25°C.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-IODO-2-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-2-METHOXYANILINE(77770-09-3)
• EPA Substance Registry System: 5-IODO-2-METHOXYANILINE(77770-09-3)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 77770-09-3(Hazardous Substances Data)

Usage

Uses

5-Iodo-2-methoxyaniline is used as a pharmaceutical intermediate.

InChI:InChI=1/C7H8INO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,9H2,1H3

Upstream product

• 364-75-0 1-fluoro-4-iodo-2-nitro-benzene 
• 696-62-8 para-iodoanisole 
• 91-23-6 2-Nitroanisole 
• 52692-09-8 4-iodo-2-nitroanisole 

Downstream Products

• 1560773-80-9 (S)-4-[3-(2-amino-3-hydroxypropanoylamino)-4-methoxyphenyl]-5,6,7-trimethoxycoumarin hydrochloride 
• 1560773-79-6 (S)-4-[3-(2-amino-3-hydroxypropanoylamino)-4-methoxyphenyl]-5,7-dimethoxycoumarin hydrochloride 
• 1560773-76-3 (S)-4-[3-(2-amino-3-hydroxypropanoylamino)-4-methoxyphenyl]-6-methoxycoumarin hydrochloride 
• 1560773-72-9 (S)-4-[3-(2-amino-3-hydroxypropanoylamino)-4-methoxyphenyl]-5-methoxycoumarin hydrochloride 
• 1560773-71-8 (S)-4-[3-(2-amino-3-hydroxypropanoylamino)-4-methoxyphenyl]coumarin hydrochloride 
• 1560773-69-4 (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,6,7-trimethoxycoumarin 
• 1560773-66-1 (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5,7-dimethoxycoumarin 
• 1560773-64-9 (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-6-methoxycoumarin 
• 1560773-61-6 (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}-5-methoxycoumarin 
• 1560773-59-2 (S)-4-{3-[3-benzyloxy-2-(tert-butoxycarbonylamino)propanoylamino]-4-methoxyphenyl}coumarin 
• 1560773-57-0 4-(3-amino-4-methoxyphenyl)-5,6,7-trimethoxycoumarin 
• 1560773-55-8 4-(3-amino-4-methoxyphenyl)-5,7-dimethoxycoumarin 
• 1560773-54-7 4-(3-amino-4-methoxyphenyl)-6-methoxycoumarin 
• 1560773-49-0 4-(3-amino-4-methoxyphenyl)-5-methoxycoumarin 

Relevant articles and documents

EP2 ANTAGONIST

A drug is provided, which containing, as an active ingredient, a compound having an antagonistic activity against an EP2 receptor in the prevention and/or treatment of a disease associated with the activation of an EP2 receptor. A compound represented by general formula (I-A): (wherein all symbols have the same meanings as those described in the specification) or a pharmaceutically acceptable salt thereof is useful as a pharmaceutical ingredient having a potent antagonistic activity against an EP2 receptor in the prevention and/or treatment of a disease associated with the activation of an EP2 receptor.

Negishi cross-coupling reaction as a route to isocombretastatins

A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC50 = 1-100 n) towards Jurkat, K562, Colo357, and A549 cell lines. Georg Thieme Verlag Stuttgart · New York.

Electrochemical C-H amination: Synthesis of aromatic primary amines via N -arylpyridinium ions

We have developed a new method for C-H amination of aromatic compounds based on electrochemical oxidation of aromatic compounds in the presence of pyridine followed by the reaction of the resulting N-arylpyridinium ions with an alkylamine. This new transformation serves as a powerful method for synthesizing aromatic primary amines from aromatic compounds without using metal catalysts and harsh chemical reagents. High chemoselectivity of the present method is demonstrated by C-H amination of aromatic compounds bearing a nitro group to give a key intermediate for the synthesis of VLA-4 antagonist.