7788-14-9

Basic information

• Product Name: 5-Phenyl-1,2,4-Oxadiazol-3-Amine
• Synonyms: 5-phenyl-1,2,4-oxadiazol-3-amine(SALTDATA: FREE);5-Phenyl-1,2,4-Oxadiazol-3-Amine
• CAS NO: 7788-14-9
• Molecular Formula: C₈H₇N₃O
• Molecular Weight: 161.16
• Product Categories: Oxadiazoles & Thiadiazoles;Heterocycles series;Amines;Oxadiazoles & Thiadiazoles
• Mol File: 7788-14-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 332.3 °C at 760 mmHg
• Flash Point: 154.7 °C
• Appearance: /
• Density: 1.276 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Chloroform (Slightly), DMSO (Sparingly)
• CAS DataBase Reference: 5-Phenyl-1,2,4-Oxadiazol-3-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Phenyl-1,2,4-Oxadiazol-3-Amine(7788-14-9)
• EPA Substance Registry System: 5-Phenyl-1,2,4-Oxadiazol-3-Amine(7788-14-9)

Safety Data

• Hazardous Substances Data: 7788-14-9(Hazardous Substances Data)

Usage

General Description

5-Phenyl-1,2,4-Oxadiazol-3-Amine is a chemical compound with the molecular formula C8H7N3O. It is a member of the oxadiazole family and consists of a phenyl ring attached to a 1,2,4-oxadiazole ring. 5-Phenyl-1,2,4-Oxadiazol-3-Amine has potential applications in medicinal chemistry, particularly as a scaffold for the development of pharmaceutical drugs. It has been studied for its potential anti-cancer, anti-bacterial, and anti-inflammatory properties. Additionally, 5-Phenyl-1,2,4-Oxadiazol-3-Amine is also used in organic synthesis and is a versatile intermediate for the preparation of various other compounds. However, caution should be taken when handling and using 5-Phenyl-1,2,4-Oxadiazol-3-Amine, as it may pose health risks and should be used in accordance with proper safety protocols.

Upstream product

• 58455-03-1 3-(benzoylamino)-5-methyl-1,2,4-oxadiazole 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 17513-09-6 N′-cyanobenzamidine 
• 1670-14-0 benzamidine monohydrochloride 
• 6041-23-2 methyl N-cyanobenzenecarboximidoate 
• 3166-00-5 benzoylguanidine 
• 6041-23-2 methyl N-cyanobenzenecarboximidoate 
• 7746-72-7 N¹-benzoyl-N³-cyanoguanidine 
• 106124-28-1 (Z)-4-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-pent-3-en-2-one 
• 96798-97-9 N-(4-phenyl-1,2,5-oxadiazol-3-yl)benzamide 
• 102140-71-6 3-(Benzoylamino)-4-methylfurazan 
• 157117-82-3 N-benzoyl-N'-benzoyloxy-guanidine 

Downstream Products

• 52770-95-3 N,N'-bis-(5-phenyl-[1,2,4]oxadiazol-3-yl)-oxalamide 
• 67560-24-1 4c-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-but-3-en-2-one 
• 52770-91-9 3-(acetylamino)-5-phenyl-1,2,4-oxadiazole 
• 54286-75-8 (Z)-3-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-but-2-enoic acid ethyl ester 
• 54286-76-9 (Z)-3-phenyl-3-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-acrylic acid ethyl ester 
• 55730-04-6 3-oxo-3-phenyl-N-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propionamide 
• 28386-96-1 1-phenyl-3-(5-phenyl-[1,2,4]oxadiazol-3-yl)-urea 
• 54356-29-5 N-(5-anilino-[1,2,4]thiadiazol-3-yl)-benzamide 
• 31709-26-9 ethyl [5-phenyl-1,2,4-oxadiazol-3-yl]imidoformate 
• 52854-32-7 4-(5-phenyl-[1,2,4]oxadiazol-3-yl)-3-thio-allophanic acid ethyl ester 
• 106124-28-1 (Z)-4-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-pent-3-en-2-one 
• 108656-02-6 (Z)-1-phenyl-3-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-but-2-en-1-one 
• 52854-30-5 2-cyano-3-(5-phenyl-[1,2,4]oxadiazol-3-ylamino)-acrylic acid ethyl ester 
• 1269105-47-6 N-(2'-(E)-butenyl)-5-phenyl-1,2,4-oxadiazol-3-one 

Relevant articles and documents

Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines

A practical convergent synthesis of PI3K inhibitor GDC-0908 (1) is described. The process features a dihydrobenzothienooxepine formation via palladium-catalyzed intramolecular direct C-H arylation and a Negishi coupling to construct the key C-C bonds. We

Facile synthesis of 3-amino-5-aryl-1,2,4-oxadiazoles: Via PIDA-mediated intramolecular oxidative cyclization

A mild and efficient method for the synthesis of 3-amino-5-aryl-1,2,4-oxadiazole by intramolecular cyclization using PhI(OAc)2 (PIDA) as an oxidant is developed. Various 3-amino-5-aryl-1,2,4-oxadiazoles are prepared in moderate to good yields,

A generalized synthesis of 3-amino-5-aryl-, 3-amino-5-polyfluorophenyl-, and 3-amino-5-alkyl-1,2,4-oxadiazoles through ring-degenerate rearrangements

A generalized synthesis of 3-amino-5-aryl-, 3-amino-5-polyfluorophenyl- and 3-amino-5-alkyl-1,2,4-oxadiazoles has been developed starting from the 3-amino-5-methyl-1,2,4-oxadiazole as a common synthon. Aroylation or alkanoylation of this aminooxadiazole,