7789-65-3Relevant articles and documents
Selenopheno[2,3-: F] coumarins: Novel scaffolds with antimetastatic activity against melanoma and breast cancer
Arsenyan, Pavel,Vasiljeva, Jelena,Domracheva, Ilona,Kanepe-Lapsa, Iveta,Gulbe, Anita
, p. 11851 - 11864 (2019)
The general aim of the current research is to find novel non-toxic small molecules with antimetastatic activity. Herein we present a series of novel selenopheno[2,3-f]coumarins with low cytotoxicity profiles against cancer cells with different natures (carcinomas, sarcomas, melanomas, neuroblastomas, and hepatomas). Based on their structure-activity relationships (SARs), few compounds selectively induce MMP inhibition and suppress angiogenesis in vivo up to 57% (10 μM). Certain derivatives are excellent agents for in vivo prevention of melanoma and breast cancer metastasis: up to 97% with no visual side effects. The present study provides scientific evidence that a selenophenocoumarin scaffold is a promising competitor for the development of drug candidates with metastasis-suppressing properties.
Electrophilic addition of selenium and telluriom halides to methyldiethynylsilane
Amosova,Penzik,Martynov,Zhilitskaya,Voronkov
, p. 221 - 227 (2009)
Regio- and stereoselective electrophilic addition reactions of SeCl 2, SeBr2, SeCl4, SeBr4 to methyldiethynylsilane lead to predominant formation of the Z-isomers of 3,6-dihalo-4-methyl-1,4-selenasilafulvenes, d
Stereoselective synthesis of (E,E)-bis(2-halovinyl) selenides and its derivatives based on selenium halides and acetylene
Musalov, Maxim V.,Potapov, Vladimir A.,Musalova, Maria V.,Amosova, Svetlana V.
, p. 10567 - 10572,6 (2012/12/12)
Efficient stereoselective synthesis of (E,E)-bis(2-chlorovinyl) and (E,E)-bis(2-bromovinyl) selenides in 95-98% yield based on the reactions of selenium dihalides or monohalides with acetylene has been elaborated. Reactions of selenium tetrahalides with a
