779-53-3

Basic information

• Product Name: Ethanone, 2-(4-morpholinyl)-1-phenyl-
• CAS NO: 779-53-3
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol File: 779-53-3.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(4-morpholinyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(4-morpholinyl)-1-phenyl-(779-53-3)
• EPA Substance Registry System: Ethanone, 2-(4-morpholinyl)-1-phenyl-(779-53-3)

Safety Data

• Hazardous Substances Data: 779-53-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 110-91-8 morpholine 
• 450-95-3 2-fluoroacetophenone 
• 98-86-2 acetophenone 
• 4136-21-4 p-methoxybenzoylmethanol 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 3282-32-4 2-diazo-acetophenone 
• 110380-87-5 4-(trans-3-phenyl-oxiranesulfonyl)-morpholine 
• 136132-07-5 3-(bromomethyl)-3-phenyl-1,2-dioxetane 
• 79409-16-8 2-diphenylphosphinoyl-2-morpholin-4-yl-1-phenyl-ethanol 
• 50-00-0 formaldehyd 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1207202-15-0 C₁₉H₂₃N₃O₃S 
• 1248740-18-2 2-phenyl-3-morpholino-5-hydroxy-benzo[g]indole 
• 1468-28-6 4-benzoylmorpholine 
• 40991-78-4 4-(phenylglyoxylyl)morpholine 
• 87837-32-9 (S)-2-(morpholin-1-yl)-1-phenylethanol 
• 110-91-8 morpholine 
• 65617-09-6 (S)-Methoxy-phenyl-acetic acid (R)-2-morpholin-4-yl-1-phenyl-ethyl ester 
• 65617-09-6 (S)-Methoxy-phenyl-acetic acid (S)-2-morpholin-4-yl-1-phenyl-ethyl ester 
• 97295-30-2 3-chloro-1,3-diphenyl-1,2-propanedione 
• 40116-78-7 (R)-2-morpholino-1-phenylethanol 
• 4432-34-2 2-morpholino-1-phenylethanol 
• 5509-99-9 2-morpholino-1-phenyl-2-thioxoethanone 
• 97315-06-5 (E)-3-Chloro-2-morpholin-4-yl-1,3-diphenyl-propenone 

Relevant articles and documents

One pot synthesis of α-N-heteroaryl ketone derivatives from aryl ketones using aqueous NaICl2

A simple and efficient method for the synthesis of α-heteroaryl ketones from aryl ketones and amine using aqueous sodium dichloroiodate is established. This method is mild, operationally simple, has a short reaction time, and easy workup procedure to afford the corresponding α-N-heteroaryl ketone derivatives in moderate to good yield.

Solvent-Free Synthesis of α-Amino Ketones from α-Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement

Heyns rearrangement have been famous for carbohydrate chemists for several decades. However, this reaction was underrated as a useful method for synthetic chemists due to preparative shortcomings. Herein we developed an efficient method for the synthesis of pharmaceutically important α-amino ketones from readily available α-hydroxy ketones and secondary amines through a tandem reaction sequence based on Heyns rearrangement. The reaction smoothly proceeded by using catalytic PTSA as catalyst without solvent. Primary and secondary α-hydroxy ketones were readily used and regioselectively afforded the correspondingly α-amino ketones with moderate yield.

Simplified heterocyclic analogues of fluoxetine inhibit inducible nitric oxide production in lipopolysaccharide-induced BV2 cells

A series of fluoxetine, where the N-methylamino group was replaced and then simplified, were synthesized and their inhibitory effect was tested for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells. Although the synthesized compounds generally revealed weaker activity or greater cytotoxicity than fluoxetine, compound 10a, in which the N-methylamino group in fluoxetine was replaced by morpholine, and the trifluoromethylphenyl ring was substituted with simple oxo group, suppressed NO production dose-dependently at 10, 20 and 40 μM concentrations with less cytotoxicity than fluoxetine, and inhibited iNOS mRNA and protein expression at the same concentrations in LPS-induced BV2 cells. The results suggested that the trifluoromethylphenyl ring moiety in fluoxetine is not necessary for the suppression of NO production and that 10a has the potential as a potent inhibitor of NO production.