78095-19-9 Usage
Description
(R)-(+)-8-Hydroxy-DPAT hydrobromide, also known as (R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, is a chiral compound that acts as a selective agonist for the 5-HT1A serotonin receptor. It is a synthetic derivative of the tetralin family and exhibits high affinity and selectivity for the 5-HT1A receptor subtype. This property makes it a valuable tool in the study of serotoninergic systems and the development of potential therapeutic agents targeting the 5-HT1A receptor.
Uses
Used in Pharmaceutical Research:
(R)-(+)-8-Hydroxy-DPAT hydrobromide is used as a 5-HT1A agonist for various research applications, including the investigation of the serotonin receptor's activity and its role in various physiological and pathological processes.
Used in Neuroscience Research:
In the field of neuroscience, (R)-(+)-8-Hydroxy-DPAT hydrobromide is used as a research tool to study the effects of 5-HT1A receptor activation on neuronal function, particularly in the hippocampus. It is employed to stimulate hippocampal neurons and evaluate the receptor's influence on learning, memory, and mood regulation.
Used in Behavioral Studies:
(R)-(+)-8-Hydroxy-DPAT hydrobromide is utilized in behavioral studies involving mice to assess the compound's impact on serotonin receptor activity and its potential effects on animal behavior, including anxiety, depression, and other mood-related disorders.
Used in Aquatic Biology Research:
In aquatic biology, (R)-(+)-8-Hydroxy-DPAT hydrobromide is used to test its effect on zebrafish melanocyte migration and survival. This application aids in understanding the role of serotonin signaling in the development and pigmentation of aquatic organisms.
Overall, (R)-(+)-8-Hydroxy-DPAT hydrobromide serves as a versatile and valuable compound in various research fields, including pharmaceutical, neuroscience, behavioral studies, and aquatic biology, due to its selective agonist properties for the 5-HT1A receptor.
Biochem/physiol Actions
(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.
Check Digit Verification of cas no
The CAS Registry Mumber 78095-19-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,0,9 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 78095-19:
(7*7)+(6*8)+(5*0)+(4*9)+(3*5)+(2*1)+(1*9)=159
159 % 10 = 9
So 78095-19-9 is a valid CAS Registry Number.
78095-19-9Relevant articles and documents
8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists
Arvidsson,Hacksell,Johansson,Nilsson,Lindberg,Sanchez,Wikstroem,Svensson,Hjorth,Carlsson
, p. 45 - 51 (2007/10/02)
A series of 2-(alkylamino)tetralins related to 8-hydroxy-2-(di-n-propylamino)tetralin (21) were prepared and tested as dopamine (DA) and 5-hydroxytryptamine (5-HT) receptor agonists. Several of the compounds were potent 5-HT agonists devoid of DA-mimetic effects. N-Ethyl or N-propyl substitution of 8-hydroxy-2-aminotetralin gave the most potent agonists. It was shown that the most potent compound, (+)-21, has the 2R configuration. 5,8-Dimethoxy-2-(di-n-propylamino)tetralin (31) was found to be a weak DA agonist devoid of 5-HT activity. The corresponding indan derivative, 4,7-dimethoxy-2-(di-n-propylamino)indan (39), has been reported to be active on both DA and 5-HT receptors. The 5-HT-stimulating properties of compounds 21 and 39 as compared to the incapability of compound 31 to activate the 5-HT receptor is tentatively explained by the assumed mode of binding of the compounds to the 5-HT receptor.
