78246-81-8Relevant articles and documents
Solid phase synthesis of muramyl dipeptides on isomeric trialkoxybenzylamine resins
Kohlbau, Hans-Jürgen,Tschakert, Jochen,Al-Qawasmeh, Raed A.,Nizami, Tanveer Ahmad,Malik, Abdul,Voelter, Wolfgang
, p. 753 - 764 (1998)
New isomeric trialkoxybenzylamine resins are developed coupling phthalimidomethyl-3,5-dimethoxyphenols to the Merrifield resin, followed by subsequent treatment with hydrazine. The generated benzylamine function allows DCC coupling with the carboxyl funct
SYNTHETIC INNATE IMMUNE RECEPTOR LIGANDS AND USES THEREOF
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Paragraph 0057, (2020/06/10)
An adjuvant formulation includes a monophosphoryl Lipid A (MPLA) analogue, a Pam3CSK4 analogue, or a muramyldipeptide (MDP) analogue, or combinations thereof. The adjuvant may be formulated in soluble form or in a nanoparticle, such as polylactic glycolic acid nanoparticles. A vaccine formulation comprises the adjuvant formulation and an immunogen. Methods of vaccinating an animal include delivering the vaccine formulation to the animal.
NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF
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Page/Page column 18; 35, (2017/06/30)
The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof. R = alkyl (both linear and branched), aryl, substituted aryl, alkoxy alkyl Wherein, R can be both linear and branched alkyl, aryl, substituted aryl and alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.